Electrocardiographic Abnormalities in Hypertension Models
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Journal of Cardiovascular Sciences (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400321 |
Resumo: | Abstract Background: Hypertensive condition can lead to abnormalities in heart structure and electrical activity. The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problem. Objective: We conducted a comparative ECG analysis between two hypertension models (L-NAME and SHR) and their controls (Wistar and Wistar-Kyoto) at six and 15 th week of age. Methods: Blood pressure was measured at the end of the 15 th week, and electrocardiography was performed at six and 15 weeks of age in anaesthetized rats. Data normality was confirmed by Kolmogorov-Smirnov test followed by unpaired Student's t-test and the Mann-Whitney for parametric and non-parametric data, respectively. Results are expressed as mean ± SD. The accepted level of significance was set at p < 0.05. Results: L-NAME exhibited prolongation of JT and QT intervals and SHR showed a decrease in heart rate when compared to Wistar-Kyoto and L-NAME. Wistar-Kyoto exhibited short PR interval with increased QRS complex, and only QT prolongation at 15 weeks compared to Wistar. Conclusions: All the hypertension models used in this study featured an increase in blood pressure. However, while SHR showed cardiac dysfunction, L-NAME exhibited changes in ventricular performance. These results may guide future studies on different types and models of hypertension. |
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Electrocardiographic Abnormalities in Hypertension ModelsRatsHypertensionBlood PressureElectrocardiography/methodsNG-Nitroarginine Methil Éster/ adverse effectsRats, Inbred (SHR)Abstract Background: Hypertensive condition can lead to abnormalities in heart structure and electrical activity. The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problem. Objective: We conducted a comparative ECG analysis between two hypertension models (L-NAME and SHR) and their controls (Wistar and Wistar-Kyoto) at six and 15 th week of age. Methods: Blood pressure was measured at the end of the 15 th week, and electrocardiography was performed at six and 15 weeks of age in anaesthetized rats. Data normality was confirmed by Kolmogorov-Smirnov test followed by unpaired Student's t-test and the Mann-Whitney for parametric and non-parametric data, respectively. Results are expressed as mean ± SD. The accepted level of significance was set at p < 0.05. Results: L-NAME exhibited prolongation of JT and QT intervals and SHR showed a decrease in heart rate when compared to Wistar-Kyoto and L-NAME. Wistar-Kyoto exhibited short PR interval with increased QRS complex, and only QT prolongation at 15 weeks compared to Wistar. Conclusions: All the hypertension models used in this study featured an increase in blood pressure. However, while SHR showed cardiac dysfunction, L-NAME exhibited changes in ventricular performance. These results may guide future studies on different types and models of hypertension.Sociedade Brasileira de Cardiologia2020-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400321International Journal of Cardiovascular Sciences v.33 n.4 2020reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.20190116info:eu-repo/semantics/openAccessConceição-Vertamatti,Ana GabrielaBorghi,FilipyIshizu,Larissa YuriCosta,Gustavo TrevisanRamos,Luiz AlbertoAreas,Miguel ArcanjoGrassi-Kassisse,Dora Mariaeng2020-08-03T00:00:00Zoai:scielo:S2359-56472020000400321Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2020-08-03T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Electrocardiographic Abnormalities in Hypertension Models |
title |
Electrocardiographic Abnormalities in Hypertension Models |
spellingShingle |
Electrocardiographic Abnormalities in Hypertension Models Conceição-Vertamatti,Ana Gabriela Rats Hypertension Blood Pressure Electrocardiography/methods NG-Nitroarginine Methil Éster/ adverse effects Rats, Inbred (SHR) |
title_short |
Electrocardiographic Abnormalities in Hypertension Models |
title_full |
Electrocardiographic Abnormalities in Hypertension Models |
title_fullStr |
Electrocardiographic Abnormalities in Hypertension Models |
title_full_unstemmed |
Electrocardiographic Abnormalities in Hypertension Models |
title_sort |
Electrocardiographic Abnormalities in Hypertension Models |
author |
Conceição-Vertamatti,Ana Gabriela |
author_facet |
Conceição-Vertamatti,Ana Gabriela Borghi,Filipy Ishizu,Larissa Yuri Costa,Gustavo Trevisan Ramos,Luiz Alberto Areas,Miguel Arcanjo Grassi-Kassisse,Dora Maria |
author_role |
author |
author2 |
Borghi,Filipy Ishizu,Larissa Yuri Costa,Gustavo Trevisan Ramos,Luiz Alberto Areas,Miguel Arcanjo Grassi-Kassisse,Dora Maria |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Conceição-Vertamatti,Ana Gabriela Borghi,Filipy Ishizu,Larissa Yuri Costa,Gustavo Trevisan Ramos,Luiz Alberto Areas,Miguel Arcanjo Grassi-Kassisse,Dora Maria |
dc.subject.por.fl_str_mv |
Rats Hypertension Blood Pressure Electrocardiography/methods NG-Nitroarginine Methil Éster/ adverse effects Rats, Inbred (SHR) |
topic |
Rats Hypertension Blood Pressure Electrocardiography/methods NG-Nitroarginine Methil Éster/ adverse effects Rats, Inbred (SHR) |
description |
Abstract Background: Hypertensive condition can lead to abnormalities in heart structure and electrical activity. The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problem. Objective: We conducted a comparative ECG analysis between two hypertension models (L-NAME and SHR) and their controls (Wistar and Wistar-Kyoto) at six and 15 th week of age. Methods: Blood pressure was measured at the end of the 15 th week, and electrocardiography was performed at six and 15 weeks of age in anaesthetized rats. Data normality was confirmed by Kolmogorov-Smirnov test followed by unpaired Student's t-test and the Mann-Whitney for parametric and non-parametric data, respectively. Results are expressed as mean ± SD. The accepted level of significance was set at p < 0.05. Results: L-NAME exhibited prolongation of JT and QT intervals and SHR showed a decrease in heart rate when compared to Wistar-Kyoto and L-NAME. Wistar-Kyoto exhibited short PR interval with increased QRS complex, and only QT prolongation at 15 weeks compared to Wistar. Conclusions: All the hypertension models used in this study featured an increase in blood pressure. However, while SHR showed cardiac dysfunction, L-NAME exhibited changes in ventricular performance. These results may guide future studies on different types and models of hypertension. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400321 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400321 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.36660/ijcs.20190116 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
International Journal of Cardiovascular Sciences v.33 n.4 2020 reponame:International Journal of Cardiovascular Sciences (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
International Journal of Cardiovascular Sciences (Online) |
collection |
International Journal of Cardiovascular Sciences (Online) |
repository.name.fl_str_mv |
International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
tailanerodrigues@cardiol.br||revistaijcs@cardiol.br |
_version_ |
1754732626530271232 |