Determinants of Arterial Stiffness and Vascular Aging in the Older Adult
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Publication Date: | 2020 |
Other Authors: | |
Format: | Article |
Language: | eng |
Source: | International Journal of Cardiovascular Sciences (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400349 |
Summary: | Abstract Background: Arterial stiffness (AS) is recognized as an important and independent risk factor for cardiovascular diseases (CVD). Objective: This study was aimed at identifying the main determinants of AS in the elderly. Design and Methods: This was an observational, cross-sectional study of elderly participants. Blood pressure (BP) and parameters of arterial function were measured using a validated device. Clinical and demographic data, global cardiovascular risk, health-related quality of life, dietary profile and cognition data were evaluated. Blood samples were collected for biochemical profiling of the participants. Handgrip strength test was performed. Student's t-test and the χ2 or Fisher exact tests were used for between-group comparisons as adequate. Correlational analysis was performed with the Pearson correlation coefficients and linear regression analysis. A two-tailed p < 0.05 was considered significant. Results: Fifty-four participants (81.8 ± 8.8 years; 65-94 years) were included in the study. Central BP was 132.7 ± 23.7 mmHg and 51.5 ± 15.7 mmHg, respectively, for aortic systolic and pulse pressures. Mean pulse wave velocity (PWV) was 12.9 ± 2.1 m/s and augmentation index 30.1 ± 12.9%. The proportion of participants with abnormal AS (increased PWV) was 27.8%. Participants with abnormal AS had higher brachial and central BP, higher BMI and higher abdominal fat. Functionality and nutritional status were worse in participants with abnormal AS. Regression analysis indicated age, brachial and central BP and vascular resistance as main determinants of AS. Conclusions: Abnormal AS is a common finding in the elderly and is highly associated with hypertension, functional decline and impairment of kidney function. |
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Determinants of Arterial Stiffness and Vascular Aging in the Older AdultVascular StiffnessHypertensionPulse Wave AnalysisCardiovascular DiseasesComorbidityRisk FactorsAbstract Background: Arterial stiffness (AS) is recognized as an important and independent risk factor for cardiovascular diseases (CVD). Objective: This study was aimed at identifying the main determinants of AS in the elderly. Design and Methods: This was an observational, cross-sectional study of elderly participants. Blood pressure (BP) and parameters of arterial function were measured using a validated device. Clinical and demographic data, global cardiovascular risk, health-related quality of life, dietary profile and cognition data were evaluated. Blood samples were collected for biochemical profiling of the participants. Handgrip strength test was performed. Student's t-test and the χ2 or Fisher exact tests were used for between-group comparisons as adequate. Correlational analysis was performed with the Pearson correlation coefficients and linear regression analysis. A two-tailed p < 0.05 was considered significant. Results: Fifty-four participants (81.8 ± 8.8 years; 65-94 years) were included in the study. Central BP was 132.7 ± 23.7 mmHg and 51.5 ± 15.7 mmHg, respectively, for aortic systolic and pulse pressures. Mean pulse wave velocity (PWV) was 12.9 ± 2.1 m/s and augmentation index 30.1 ± 12.9%. The proportion of participants with abnormal AS (increased PWV) was 27.8%. Participants with abnormal AS had higher brachial and central BP, higher BMI and higher abdominal fat. Functionality and nutritional status were worse in participants with abnormal AS. Regression analysis indicated age, brachial and central BP and vascular resistance as main determinants of AS. Conclusions: Abnormal AS is a common finding in the elderly and is highly associated with hypertension, functional decline and impairment of kidney function.Sociedade Brasileira de Cardiologia2020-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400349International Journal of Cardiovascular Sciences v.33 n.4 2020reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.20190068info:eu-repo/semantics/openAccessPereira,TelmoCosta,Tatianaeng2020-08-03T00:00:00Zoai:scielo:S2359-56472020000400349Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2020-08-03T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
title |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
spellingShingle |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult Pereira,Telmo Vascular Stiffness Hypertension Pulse Wave Analysis Cardiovascular Diseases Comorbidity Risk Factors |
title_short |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
title_full |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
title_fullStr |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
title_full_unstemmed |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
title_sort |
Determinants of Arterial Stiffness and Vascular Aging in the Older Adult |
author |
Pereira,Telmo |
author_facet |
Pereira,Telmo Costa,Tatiana |
author_role |
author |
author2 |
Costa,Tatiana |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Pereira,Telmo Costa,Tatiana |
dc.subject.por.fl_str_mv |
Vascular Stiffness Hypertension Pulse Wave Analysis Cardiovascular Diseases Comorbidity Risk Factors |
topic |
Vascular Stiffness Hypertension Pulse Wave Analysis Cardiovascular Diseases Comorbidity Risk Factors |
description |
Abstract Background: Arterial stiffness (AS) is recognized as an important and independent risk factor for cardiovascular diseases (CVD). Objective: This study was aimed at identifying the main determinants of AS in the elderly. Design and Methods: This was an observational, cross-sectional study of elderly participants. Blood pressure (BP) and parameters of arterial function were measured using a validated device. Clinical and demographic data, global cardiovascular risk, health-related quality of life, dietary profile and cognition data were evaluated. Blood samples were collected for biochemical profiling of the participants. Handgrip strength test was performed. Student's t-test and the χ2 or Fisher exact tests were used for between-group comparisons as adequate. Correlational analysis was performed with the Pearson correlation coefficients and linear regression analysis. A two-tailed p < 0.05 was considered significant. Results: Fifty-four participants (81.8 ± 8.8 years; 65-94 years) were included in the study. Central BP was 132.7 ± 23.7 mmHg and 51.5 ± 15.7 mmHg, respectively, for aortic systolic and pulse pressures. Mean pulse wave velocity (PWV) was 12.9 ± 2.1 m/s and augmentation index 30.1 ± 12.9%. The proportion of participants with abnormal AS (increased PWV) was 27.8%. Participants with abnormal AS had higher brachial and central BP, higher BMI and higher abdominal fat. Functionality and nutritional status were worse in participants with abnormal AS. Regression analysis indicated age, brachial and central BP and vascular resistance as main determinants of AS. Conclusions: Abnormal AS is a common finding in the elderly and is highly associated with hypertension, functional decline and impairment of kidney function. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400349 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472020000400349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.36660/ijcs.20190068 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia |
dc.source.none.fl_str_mv |
International Journal of Cardiovascular Sciences v.33 n.4 2020 reponame:International Journal of Cardiovascular Sciences (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
International Journal of Cardiovascular Sciences (Online) |
collection |
International Journal of Cardiovascular Sciences (Online) |
repository.name.fl_str_mv |
International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
tailanerodrigues@cardiol.br||revistaijcs@cardiol.br |
_version_ |
1754732626523979776 |