Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome

Detalhes bibliográficos
Autor(a) principal: Soares,Fábia C. S.
Data de Publicação: 2022
Outros Autores: Araújo,Romário M., Werkhauser,Roberto P., Diniz,George T., Bhaskar,Lakkakula V.K.S, Carvalho,Viviane D. C. V., Tashiro,Tetsuo, Amorim,Ester A. S., Silva,Lilian C. A., Montenegro,Sergio Tavares, Neco,Heytor V. P. C., Moraes,Clarice N. L., Martins,Danyelly B. G., Montenegro,Silvia M. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Journal of Cardiovascular Sciences (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472022000400444
Resumo: Abstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 ACS patients and 278 healthy controls were selected for this study. Four variants in NPY and two variants in NPY2R genes were genotyped using Taqman allelic discrimination and sequencing. The Chi-square and Fisher's exact tests were used to verify the genotype frequencies. The logistic regression analyses were used for the evaluation of the studied variables. Haplotype analysis was used to evaluate the linkage disequilibrium (LD) between the variants (p<0.05). Results An association of NPY c.20T>C variant was found with the ACS group when compared to the healthy group. In the analysis between variants and risk factors in the ACS group, NPY c.84G>A was associated with hypertension. The analysis between TIMI risk showed a significance for NPY c.20T>C between the low and intermediate/high TIMI risk groups. In the haplotype analysis, strong linkage disequilibrium (LD) was found between the variants NPY c.150G>A and NPY c.-485T>C. Conclusion The NPY c.20T>C variant appears to contribute to the development of ACS. The NPY2R c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension. In addition, the NPY c.20T>C is associated with a protective effect in ACS severity.
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spelling Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary SyndromeAcute Coronary SyndromeNeuropeptide YReceptors Neuropeptide YNucleotide PolymorphismEpidemiologyAbstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 ACS patients and 278 healthy controls were selected for this study. Four variants in NPY and two variants in NPY2R genes were genotyped using Taqman allelic discrimination and sequencing. The Chi-square and Fisher's exact tests were used to verify the genotype frequencies. The logistic regression analyses were used for the evaluation of the studied variables. Haplotype analysis was used to evaluate the linkage disequilibrium (LD) between the variants (p<0.05). Results An association of NPY c.20T>C variant was found with the ACS group when compared to the healthy group. In the analysis between variants and risk factors in the ACS group, NPY c.84G>A was associated with hypertension. The analysis between TIMI risk showed a significance for NPY c.20T>C between the low and intermediate/high TIMI risk groups. In the haplotype analysis, strong linkage disequilibrium (LD) was found between the variants NPY c.150G>A and NPY c.-485T>C. Conclusion The NPY c.20T>C variant appears to contribute to the development of ACS. The NPY2R c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension. In addition, the NPY c.20T>C is associated with a protective effect in ACS severity.Sociedade Brasileira de Cardiologia2022-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472022000400444International Journal of Cardiovascular Sciences v.35 n.4 2022reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/ijcs.20210053info:eu-repo/semantics/openAccessSoares,Fábia C. S.Araújo,Romário M.Werkhauser,Roberto P.Diniz,George T.Bhaskar,Lakkakula V.K.SCarvalho,Viviane D. C. V.Tashiro,TetsuoAmorim,Ester A. S.Silva,Lilian C. A.Montenegro,Sergio TavaresNeco,Heytor V. P. C.Moraes,Clarice N. L.Martins,Danyelly B. G.Montenegro,Silvia M. L.eng2022-08-01T00:00:00Zoai:scielo:S2359-56472022000400444Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2022-08-01T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
title Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
spellingShingle Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
Soares,Fábia C. S.
Acute Coronary Syndrome
Neuropeptide Y
Receptors Neuropeptide Y
Nucleotide Polymorphism
Epidemiology
title_short Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
title_full Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
title_fullStr Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
title_full_unstemmed Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
title_sort Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
author Soares,Fábia C. S.
author_facet Soares,Fábia C. S.
Araújo,Romário M.
Werkhauser,Roberto P.
Diniz,George T.
Bhaskar,Lakkakula V.K.S
Carvalho,Viviane D. C. V.
Tashiro,Tetsuo
Amorim,Ester A. S.
Silva,Lilian C. A.
Montenegro,Sergio Tavares
Neco,Heytor V. P. C.
Moraes,Clarice N. L.
Martins,Danyelly B. G.
Montenegro,Silvia M. L.
author_role author
author2 Araújo,Romário M.
Werkhauser,Roberto P.
Diniz,George T.
Bhaskar,Lakkakula V.K.S
Carvalho,Viviane D. C. V.
Tashiro,Tetsuo
Amorim,Ester A. S.
Silva,Lilian C. A.
Montenegro,Sergio Tavares
Neco,Heytor V. P. C.
Moraes,Clarice N. L.
Martins,Danyelly B. G.
Montenegro,Silvia M. L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares,Fábia C. S.
Araújo,Romário M.
Werkhauser,Roberto P.
Diniz,George T.
Bhaskar,Lakkakula V.K.S
Carvalho,Viviane D. C. V.
Tashiro,Tetsuo
Amorim,Ester A. S.
Silva,Lilian C. A.
Montenegro,Sergio Tavares
Neco,Heytor V. P. C.
Moraes,Clarice N. L.
Martins,Danyelly B. G.
Montenegro,Silvia M. L.
dc.subject.por.fl_str_mv Acute Coronary Syndrome
Neuropeptide Y
Receptors Neuropeptide Y
Nucleotide Polymorphism
Epidemiology
topic Acute Coronary Syndrome
Neuropeptide Y
Receptors Neuropeptide Y
Nucleotide Polymorphism
Epidemiology
description Abstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 ACS patients and 278 healthy controls were selected for this study. Four variants in NPY and two variants in NPY2R genes were genotyped using Taqman allelic discrimination and sequencing. The Chi-square and Fisher's exact tests were used to verify the genotype frequencies. The logistic regression analyses were used for the evaluation of the studied variables. Haplotype analysis was used to evaluate the linkage disequilibrium (LD) between the variants (p<0.05). Results An association of NPY c.20T>C variant was found with the ACS group when compared to the healthy group. In the analysis between variants and risk factors in the ACS group, NPY c.84G>A was associated with hypertension. The analysis between TIMI risk showed a significance for NPY c.20T>C between the low and intermediate/high TIMI risk groups. In the haplotype analysis, strong linkage disequilibrium (LD) was found between the variants NPY c.150G>A and NPY c.-485T>C. Conclusion The NPY c.20T>C variant appears to contribute to the development of ACS. The NPY2R c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension. In addition, the NPY c.20T>C is associated with a protective effect in ACS severity.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472022000400444
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472022000400444
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.36660/ijcs.20210053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv International Journal of Cardiovascular Sciences v.35 n.4 2022
reponame:International Journal of Cardiovascular Sciences (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str International Journal of Cardiovascular Sciences (Online)
collection International Journal of Cardiovascular Sciences (Online)
repository.name.fl_str_mv International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv tailanerodrigues@cardiol.br||revistaijcs@cardiol.br
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