MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm

Detalhes bibliográficos
Autor(a) principal: Joviliano,Edwaldo Edner
Data de Publicação: 2017
Outros Autores: Ribeiro,Mauricio Serra, Tenorio,Emanuel Junior Ramos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Cardiovascular Surgery (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215
Resumo: Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.
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spelling MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic AneurysmAortic AneurysmAortic Aneurysm, AbdominalMicroRNAsAbstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.Sociedade Brasileira de Cirurgia Cardiovascular2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215Brazilian Journal of Cardiovascular Surgery v.32 n.3 2017reponame:Brazilian Journal of Cardiovascular Surgery (Online)instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)instacron:SBCCV10.21470/1678-9741-2016-0050info:eu-repo/semantics/openAccessJoviliano,Edwaldo EdnerRibeiro,Mauricio SerraTenorio,Emanuel Junior Ramoseng2017-08-14T00:00:00Zoai:scielo:S0102-76382017000300215Revistahttp://www.rbccv.org.br/https://old.scielo.br/oai/scielo-oai.php||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br1678-97410102-7638opendoar:2017-08-14T00:00Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)false
dc.title.none.fl_str_mv MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
title MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
spellingShingle MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
Joviliano,Edwaldo Edner
Aortic Aneurysm
Aortic Aneurysm, Abdominal
MicroRNAs
title_short MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
title_full MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
title_fullStr MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
title_full_unstemmed MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
title_sort MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
author Joviliano,Edwaldo Edner
author_facet Joviliano,Edwaldo Edner
Ribeiro,Mauricio Serra
Tenorio,Emanuel Junior Ramos
author_role author
author2 Ribeiro,Mauricio Serra
Tenorio,Emanuel Junior Ramos
author2_role author
author
dc.contributor.author.fl_str_mv Joviliano,Edwaldo Edner
Ribeiro,Mauricio Serra
Tenorio,Emanuel Junior Ramos
dc.subject.por.fl_str_mv Aortic Aneurysm
Aortic Aneurysm, Abdominal
MicroRNAs
topic Aortic Aneurysm
Aortic Aneurysm, Abdominal
MicroRNAs
description Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382017000300215
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21470/1678-9741-2016-0050
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
dc.source.none.fl_str_mv Brazilian Journal of Cardiovascular Surgery v.32 n.3 2017
reponame:Brazilian Journal of Cardiovascular Surgery (Online)
instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
instacron:SBCCV
instname_str Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
instacron_str SBCCV
institution SBCCV
reponame_str Brazilian Journal of Cardiovascular Surgery (Online)
collection Brazilian Journal of Cardiovascular Surgery (Online)
repository.name.fl_str_mv Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
repository.mail.fl_str_mv ||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br
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