Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia

Detalhes bibliográficos
Autor(a) principal: Lima,Paulo Roberto da Silva
Data de Publicação: 2016
Outros Autores: Bandeira,Francisco Chavier Vieira, Rolim,Janio Cipriano, Nogueira,Manuel Ricardo Sena, Pordeus,Mizael Armando Abrantes, Oliveira,Andressa Feitosa Bezerra de, Pitta,Guilherme Benjamin Brandão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Cardiovascular Surgery (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291
Resumo: Abstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.
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spelling Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal HyperplasiaHyperplasiaGarlicRabbitsAbstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.Sociedade Brasileira de Cirurgia Cardiovascular2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291Brazilian Journal of Cardiovascular Surgery v.31 n.4 2016reponame:Brazilian Journal of Cardiovascular Surgery (Online)instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)instacron:SBCCV10.5935/1678-9741.20160069info:eu-repo/semantics/openAccessLima,Paulo Roberto da SilvaBandeira,Francisco Chavier VieiraRolim,Janio CiprianoNogueira,Manuel Ricardo SenaPordeus,Mizael Armando AbrantesOliveira,Andressa Feitosa Bezerra dePitta,Guilherme Benjamin Brandãoeng2016-11-07T00:00:00Zoai:scielo:S0102-76382016000400291Revistahttp://www.rbccv.org.br/https://old.scielo.br/oai/scielo-oai.php||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br1678-97410102-7638opendoar:2016-11-07T00:00Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)false
dc.title.none.fl_str_mv Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
title Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
spellingShingle Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
Lima,Paulo Roberto da Silva
Hyperplasia
Garlic
Rabbits
title_short Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
title_full Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
title_fullStr Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
title_full_unstemmed Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
title_sort Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
author Lima,Paulo Roberto da Silva
author_facet Lima,Paulo Roberto da Silva
Bandeira,Francisco Chavier Vieira
Rolim,Janio Cipriano
Nogueira,Manuel Ricardo Sena
Pordeus,Mizael Armando Abrantes
Oliveira,Andressa Feitosa Bezerra de
Pitta,Guilherme Benjamin Brandão
author_role author
author2 Bandeira,Francisco Chavier Vieira
Rolim,Janio Cipriano
Nogueira,Manuel Ricardo Sena
Pordeus,Mizael Armando Abrantes
Oliveira,Andressa Feitosa Bezerra de
Pitta,Guilherme Benjamin Brandão
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Paulo Roberto da Silva
Bandeira,Francisco Chavier Vieira
Rolim,Janio Cipriano
Nogueira,Manuel Ricardo Sena
Pordeus,Mizael Armando Abrantes
Oliveira,Andressa Feitosa Bezerra de
Pitta,Guilherme Benjamin Brandão
dc.subject.por.fl_str_mv Hyperplasia
Garlic
Rabbits
topic Hyperplasia
Garlic
Rabbits
description Abstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1678-9741.20160069
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
dc.source.none.fl_str_mv Brazilian Journal of Cardiovascular Surgery v.31 n.4 2016
reponame:Brazilian Journal of Cardiovascular Surgery (Online)
instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
instacron:SBCCV
instname_str Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
instacron_str SBCCV
institution SBCCV
reponame_str Brazilian Journal of Cardiovascular Surgery (Online)
collection Brazilian Journal of Cardiovascular Surgery (Online)
repository.name.fl_str_mv Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)
repository.mail.fl_str_mv ||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br
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