Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Cardiovascular Surgery (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291 |
Resumo: | Abstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol. |
id |
SBCCV-1_f14a67f6a550ab9f683c19c6730ab476 |
---|---|
oai_identifier_str |
oai:scielo:S0102-76382016000400291 |
network_acronym_str |
SBCCV-1 |
network_name_str |
Brazilian Journal of Cardiovascular Surgery (Online) |
repository_id_str |
|
spelling |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal HyperplasiaHyperplasiaGarlicRabbitsAbstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.Sociedade Brasileira de Cirurgia Cardiovascular2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291Brazilian Journal of Cardiovascular Surgery v.31 n.4 2016reponame:Brazilian Journal of Cardiovascular Surgery (Online)instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)instacron:SBCCV10.5935/1678-9741.20160069info:eu-repo/semantics/openAccessLima,Paulo Roberto da SilvaBandeira,Francisco Chavier VieiraRolim,Janio CiprianoNogueira,Manuel Ricardo SenaPordeus,Mizael Armando AbrantesOliveira,Andressa Feitosa Bezerra dePitta,Guilherme Benjamin Brandãoeng2016-11-07T00:00:00Zoai:scielo:S0102-76382016000400291Revistahttp://www.rbccv.org.br/https://old.scielo.br/oai/scielo-oai.php||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br1678-97410102-7638opendoar:2016-11-07T00:00Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV)false |
dc.title.none.fl_str_mv |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
title |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
spellingShingle |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia Lima,Paulo Roberto da Silva Hyperplasia Garlic Rabbits |
title_short |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
title_full |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
title_fullStr |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
title_full_unstemmed |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
title_sort |
Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia |
author |
Lima,Paulo Roberto da Silva |
author_facet |
Lima,Paulo Roberto da Silva Bandeira,Francisco Chavier Vieira Rolim,Janio Cipriano Nogueira,Manuel Ricardo Sena Pordeus,Mizael Armando Abrantes Oliveira,Andressa Feitosa Bezerra de Pitta,Guilherme Benjamin Brandão |
author_role |
author |
author2 |
Bandeira,Francisco Chavier Vieira Rolim,Janio Cipriano Nogueira,Manuel Ricardo Sena Pordeus,Mizael Armando Abrantes Oliveira,Andressa Feitosa Bezerra de Pitta,Guilherme Benjamin Brandão |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Paulo Roberto da Silva Bandeira,Francisco Chavier Vieira Rolim,Janio Cipriano Nogueira,Manuel Ricardo Sena Pordeus,Mizael Armando Abrantes Oliveira,Andressa Feitosa Bezerra de Pitta,Guilherme Benjamin Brandão |
dc.subject.por.fl_str_mv |
Hyperplasia Garlic Rabbits |
topic |
Hyperplasia Garlic Rabbits |
description |
Abstract Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1678-9741.20160069 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Cardiovascular |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Cardiovascular |
dc.source.none.fl_str_mv |
Brazilian Journal of Cardiovascular Surgery v.31 n.4 2016 reponame:Brazilian Journal of Cardiovascular Surgery (Online) instname:Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) instacron:SBCCV |
instname_str |
Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) |
instacron_str |
SBCCV |
institution |
SBCCV |
reponame_str |
Brazilian Journal of Cardiovascular Surgery (Online) |
collection |
Brazilian Journal of Cardiovascular Surgery (Online) |
repository.name.fl_str_mv |
Brazilian Journal of Cardiovascular Surgery (Online) - Sociedade Brasileira de Cirurgia Cardiovascular (SBCCV) |
repository.mail.fl_str_mv |
||rosangela.monteiro@incor.usp.br|| domingo@braile.com.br|| brandau@braile.com.br |
_version_ |
1752126599405240320 |