ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC

Detalhes bibliográficos
Autor(a) principal: Bardonova,Liudmila Andreevna
Data de Publicação: 2018
Outros Autores: Sheikh,Omar, Malova,Irina Olegovna, Sorokovikov,Vladimir Alexeevich, Byvaltsev,Vadim Anatolyevich
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Coluna/Columna
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237
Resumo: ABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment.
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spelling ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISCIntervertebral discNucleus pulposusAnnulus fibrosusEnergy metabolismCell therapyABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment.Sociedade Brasileira de Coluna2018-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237Coluna/Columna v.17 n.3 2018reponame:Coluna/Columnainstname:Sociedade Brasileira de Coluna (SBCO)instacron:SBCO10.1590/s1808-185120181703193837info:eu-repo/semantics/openAccessBardonova,Liudmila AndreevnaSheikh,OmarMalova,Irina OlegovnaSorokovikov,Vladimir AlexeevichByvaltsev,Vadim Anatolyevicheng2018-09-13T00:00:00Zoai:scielo:S1808-18512018000300237Revistahttps://www.revistacoluna.org/ONGhttps://old.scielo.br/oai/scielo-oai.phpcoluna.columna@uol.com.br||revistacoluna@uol.com.br2177-014X1808-1851opendoar:2018-09-13T00:00Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)false
dc.title.none.fl_str_mv ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
title ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
spellingShingle ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
Bardonova,Liudmila Andreevna
Intervertebral disc
Nucleus pulposus
Annulus fibrosus
Energy metabolism
Cell therapy
title_short ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
title_full ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
title_fullStr ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
title_full_unstemmed ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
title_sort ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
author Bardonova,Liudmila Andreevna
author_facet Bardonova,Liudmila Andreevna
Sheikh,Omar
Malova,Irina Olegovna
Sorokovikov,Vladimir Alexeevich
Byvaltsev,Vadim Anatolyevich
author_role author
author2 Sheikh,Omar
Malova,Irina Olegovna
Sorokovikov,Vladimir Alexeevich
Byvaltsev,Vadim Anatolyevich
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bardonova,Liudmila Andreevna
Sheikh,Omar
Malova,Irina Olegovna
Sorokovikov,Vladimir Alexeevich
Byvaltsev,Vadim Anatolyevich
dc.subject.por.fl_str_mv Intervertebral disc
Nucleus pulposus
Annulus fibrosus
Energy metabolism
Cell therapy
topic Intervertebral disc
Nucleus pulposus
Annulus fibrosus
Energy metabolism
Cell therapy
description ABSTRACT The intervertebral disc (IVD) is one of the parts of the body most commonly affected by disease, and it is only recently that we have come closer to understanding the reasons for its degeneration, in which nutrient supply plays a crucial role. In this literature review, we discuss the basic principles and characteristics of energy supply and demand to the IVD. Specifically, we review how different metabolites influence IVD cell activity, the effects of mechanical loading on IVD cell metabolism, and differences in energy metabolism of the annulus fibrous and nucleus pulposus cell phenotypes. Determining the factors that influence nutrient supply and demand in the IVD will enhance our understanding of the IVD pathology, and help to elucidate new therapeutic targets for IVD degeneration treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512018000300237
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1808-185120181703193837
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Coluna
publisher.none.fl_str_mv Sociedade Brasileira de Coluna
dc.source.none.fl_str_mv Coluna/Columna v.17 n.3 2018
reponame:Coluna/Columna
instname:Sociedade Brasileira de Coluna (SBCO)
instacron:SBCO
instname_str Sociedade Brasileira de Coluna (SBCO)
instacron_str SBCO
institution SBCO
reponame_str Coluna/Columna
collection Coluna/Columna
repository.name.fl_str_mv Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)
repository.mail.fl_str_mv coluna.columna@uol.com.br||revistacoluna@uol.com.br
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