SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY

Detalhes bibliográficos
Autor(a) principal: KOFF,MARCO ANTONIO EDUARDO
Data de Publicação: 2017
Outros Autores: AJIBOYE,LUKMAN OLALEKAN, LISBOA,NATÁLIA DIEL, FALAVIGNA,ASDRUBAL
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Coluna/Columna
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067
Resumo: ABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible.
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spelling SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPYAntioxidantsSpinal cord injuriesNeurologyNeurosurgeryReviewABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible.Sociedade Brasileira de Coluna2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067Coluna/Columna v.16 n.1 2017reponame:Coluna/Columnainstname:Sociedade Brasileira de Coluna (SBCO)instacron:SBCO10.1590/s1808-1851201716011171639info:eu-repo/semantics/openAccessKOFF,MARCO ANTONIO EDUARDOAJIBOYE,LUKMAN OLALEKANLISBOA,NATÁLIA DIELFALAVIGNA,ASDRUBALeng2017-04-11T00:00:00Zoai:scielo:S1808-18512017000100067Revistahttps://www.revistacoluna.org/ONGhttps://old.scielo.br/oai/scielo-oai.phpcoluna.columna@uol.com.br||revistacoluna@uol.com.br2177-014X1808-1851opendoar:2017-04-11T00:00Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)false
dc.title.none.fl_str_mv SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
title SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
spellingShingle SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
KOFF,MARCO ANTONIO EDUARDO
Antioxidants
Spinal cord injuries
Neurology
Neurosurgery
Review
title_short SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
title_full SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
title_fullStr SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
title_full_unstemmed SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
title_sort SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
author KOFF,MARCO ANTONIO EDUARDO
author_facet KOFF,MARCO ANTONIO EDUARDO
AJIBOYE,LUKMAN OLALEKAN
LISBOA,NATÁLIA DIEL
FALAVIGNA,ASDRUBAL
author_role author
author2 AJIBOYE,LUKMAN OLALEKAN
LISBOA,NATÁLIA DIEL
FALAVIGNA,ASDRUBAL
author2_role author
author
author
dc.contributor.author.fl_str_mv KOFF,MARCO ANTONIO EDUARDO
AJIBOYE,LUKMAN OLALEKAN
LISBOA,NATÁLIA DIEL
FALAVIGNA,ASDRUBAL
dc.subject.por.fl_str_mv Antioxidants
Spinal cord injuries
Neurology
Neurosurgery
Review
topic Antioxidants
Spinal cord injuries
Neurology
Neurosurgery
Review
description ABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1808-1851201716011171639
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Coluna
publisher.none.fl_str_mv Sociedade Brasileira de Coluna
dc.source.none.fl_str_mv Coluna/Columna v.16 n.1 2017
reponame:Coluna/Columna
instname:Sociedade Brasileira de Coluna (SBCO)
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instname_str Sociedade Brasileira de Coluna (SBCO)
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reponame_str Coluna/Columna
collection Coluna/Columna
repository.name.fl_str_mv Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)
repository.mail.fl_str_mv coluna.columna@uol.com.br||revistacoluna@uol.com.br
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