Efficacy of Baccharis dracunculifolia in the treatment of diversion colitis in rats

• Autor(a) principal: Lima,Arthur Medeiros
• Data de Publicação: 2020
• Outros Autores: Nascimento,Carlos Eduardo Costa, Santos,Carlos Henrique Marques dos, Dourado,Doroty Mesquita, Siqueira,Gabriel Elias Cardoso, Rigo,Giovana Maria, Bernardi,Lauren Umpierre, Leonel,Paulo Otávio Souza, Matias,Rosemary, Ferreira,Vitor Caldas, Souza,Vitor Cruz Rosa Pires de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632020000100061
• topic: Baccharis dracunculifolia; Asteraceae; Colitis; Anti-inflammatory; Rats; Colostomy

Abstract Rationale Disuse colitis is frequent in our country and the most effective treatment is high cost and there is a need for effective and low cost therapy. Objective To evaluate the efficacy of Baccharis dracunculifolia (field rosemary) in the treatment of exclusion colitis in rats. Method Eighteen Wistar rats were anesthetized and submitted to colostomy; they were then distributed into two groups: Control Group, receiving intrarectal saline infusion (n = 8) and Group BD receiving intrarectal infusion ofBaccharis dracunculifolia extract (n = 10); after 21 days of treatment they were euthanized, the intestinal segment excluded from intestinal transit was resected and submitted to histopathological study, classifying the degree of inflammation and degree of vascular congestion from 0 to 3. Results Mean inflammation was 2.7 in Control Group versus 2.1 in BD Group (p = 0.049), while mean vascular congestion was 2.3 and 2, respectively, in Control and BD groups (p = 0.1642). Conclusion Intra-rectal infusion ofBaccharis dracunculifolia extract significantly minimized the inflammatory process in the exclusion colitis of rats submitted to colostomy, without altering the degree of vascular congestion.