The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632013000300126 |
Resumo: | PURPOSE: to study 75 familial adenomatous polyposis (FAP) patients treated in a single institution in Ribeirão Preto/SP, from January 1981 to December 2011. METHODS: this is a retrospective study and the following data were collected: gender, age, main symptoms, familial history, coexisting malignancies, surgical treatment, surgical morbidity and mortality, factors related to life quality. RESULTS: median age was 29 years. Male-to-female ratio was 1.2:1. Bleeding was the most common symptom (62.6%). Colorectal cancer incidence was 25.5% (n = 19). Extracolonic neoplasia incidence was 8%. Colectomy with ileorectal anastomosis (IRA) was performed in 72% of the patients. Eighteen patients (24%) were submitted to proctocolectomy with "J-pouch" ileoanal anastomosis. In three patients (4%) proctocolectomy with terminal ileostomy was performed. Early and late complication rate were similar (22.7% × 24%). Ileal pouch surgery exhibited tendency to a higher morbidity and mortality but no significance could be found. Overall mortality rate was 7.46%. Malignant neoplasia was the main cause of mortality, accounting for 60% of deaths. CONCLUSION: FAP is a rare pathology in our country. Genetic counseling and proper screening programs are essential tools to early diagnosis and follow-up. Surgery is the most effective treatment and the best option to prevent malignant neoplasia. |
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The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão PretoFamilial adenomatousColorectal cancerIleal pouch PURPOSE: to study 75 familial adenomatous polyposis (FAP) patients treated in a single institution in Ribeirão Preto/SP, from January 1981 to December 2011. METHODS: this is a retrospective study and the following data were collected: gender, age, main symptoms, familial history, coexisting malignancies, surgical treatment, surgical morbidity and mortality, factors related to life quality. RESULTS: median age was 29 years. Male-to-female ratio was 1.2:1. Bleeding was the most common symptom (62.6%). Colorectal cancer incidence was 25.5% (n = 19). Extracolonic neoplasia incidence was 8%. Colectomy with ileorectal anastomosis (IRA) was performed in 72% of the patients. Eighteen patients (24%) were submitted to proctocolectomy with "J-pouch" ileoanal anastomosis. In three patients (4%) proctocolectomy with terminal ileostomy was performed. Early and late complication rate were similar (22.7% × 24%). Ileal pouch surgery exhibited tendency to a higher morbidity and mortality but no significance could be found. Overall mortality rate was 7.46%. Malignant neoplasia was the main cause of mortality, accounting for 60% of deaths. CONCLUSION: FAP is a rare pathology in our country. Genetic counseling and proper screening programs are essential tools to early diagnosis and follow-up. Surgery is the most effective treatment and the best option to prevent malignant neoplasia. Sociedade Brasileira de Coloproctologia2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632013000300126Journal of Coloproctology (Rio de Janeiro) v.33 n.3 2013reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2013.06.003info:eu-repo/semantics/openAccessFeitosa,Marley RibeiroOliveira,Tais Helena Garcia Fernandes deKondo,Bruno Ravenna PinheiroLira,Haline Gomes deAbissamra,André AntonioParra,Rogério SerafimFéres,OmarRocha,Jose Joaquim Ribeiro daeng2015-10-26T00:00:00Zoai:scielo:S2237-93632013000300126Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2015-10-26T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
title |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
spellingShingle |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto Feitosa,Marley Ribeiro Familial adenomatous Colorectal cancer Ileal pouch |
title_short |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
title_full |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
title_fullStr |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
title_full_unstemmed |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
title_sort |
The epidemiological and clinical features of familial adenomatous polyposis in Ribeirão Preto |
author |
Feitosa,Marley Ribeiro |
author_facet |
Feitosa,Marley Ribeiro Oliveira,Tais Helena Garcia Fernandes de Kondo,Bruno Ravenna Pinheiro Lira,Haline Gomes de Abissamra,André Antonio Parra,Rogério Serafim Féres,Omar Rocha,Jose Joaquim Ribeiro da |
author_role |
author |
author2 |
Oliveira,Tais Helena Garcia Fernandes de Kondo,Bruno Ravenna Pinheiro Lira,Haline Gomes de Abissamra,André Antonio Parra,Rogério Serafim Féres,Omar Rocha,Jose Joaquim Ribeiro da |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Feitosa,Marley Ribeiro Oliveira,Tais Helena Garcia Fernandes de Kondo,Bruno Ravenna Pinheiro Lira,Haline Gomes de Abissamra,André Antonio Parra,Rogério Serafim Féres,Omar Rocha,Jose Joaquim Ribeiro da |
dc.subject.por.fl_str_mv |
Familial adenomatous Colorectal cancer Ileal pouch |
topic |
Familial adenomatous Colorectal cancer Ileal pouch |
description |
PURPOSE: to study 75 familial adenomatous polyposis (FAP) patients treated in a single institution in Ribeirão Preto/SP, from January 1981 to December 2011. METHODS: this is a retrospective study and the following data were collected: gender, age, main symptoms, familial history, coexisting malignancies, surgical treatment, surgical morbidity and mortality, factors related to life quality. RESULTS: median age was 29 years. Male-to-female ratio was 1.2:1. Bleeding was the most common symptom (62.6%). Colorectal cancer incidence was 25.5% (n = 19). Extracolonic neoplasia incidence was 8%. Colectomy with ileorectal anastomosis (IRA) was performed in 72% of the patients. Eighteen patients (24%) were submitted to proctocolectomy with "J-pouch" ileoanal anastomosis. In three patients (4%) proctocolectomy with terminal ileostomy was performed. Early and late complication rate were similar (22.7% × 24%). Ileal pouch surgery exhibited tendency to a higher morbidity and mortality but no significance could be found. Overall mortality rate was 7.46%. Malignant neoplasia was the main cause of mortality, accounting for 60% of deaths. CONCLUSION: FAP is a rare pathology in our country. Genetic counseling and proper screening programs are essential tools to early diagnosis and follow-up. Surgery is the most effective treatment and the best option to prevent malignant neoplasia. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632013000300126 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632013000300126 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2013.06.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.33 n.3 2013 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
_version_ |
1752126477386645504 |