Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000300240 |
Resumo: | ABSTRACT Crohn's disease has an ever-increasing prevalence and incidence, with about 20% of patients developing perianal fistula with significant impact on their quality of life. Despite the medical and surgical treatments currently used, Crohn's-related fistula treatment continues to pose a challenge due to the low rates of efficacy associated with high recurrence rates. Recent clinical trials have shown promising results regarding safety and efficacy of local treatment of this condition with the use of adipose tissue-derived mesenchymal stem cells. Besides being pluripotent and poorly immunogenic, they have immunomodulatory and anti-inflammatory properties, which combined, may accelerate healing. Our main objective is to summarize the clinical trials we found, highlighting the efficacy rates of this therapy and the main limitations we found in the analysis of the results. We conclude that, in perianal fistulas refractory to conventional therapies, the treatment with adipose tissue-derived mesenchymal cells is safe with promising results that may change the current paradigm of Crohn's related fistula treatment. |
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Journal of Coloproctology (Rio de Janeiro. Online) |
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Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulaeCrohn's diseaseFistulaAdipose tissueStem cellABSTRACT Crohn's disease has an ever-increasing prevalence and incidence, with about 20% of patients developing perianal fistula with significant impact on their quality of life. Despite the medical and surgical treatments currently used, Crohn's-related fistula treatment continues to pose a challenge due to the low rates of efficacy associated with high recurrence rates. Recent clinical trials have shown promising results regarding safety and efficacy of local treatment of this condition with the use of adipose tissue-derived mesenchymal stem cells. Besides being pluripotent and poorly immunogenic, they have immunomodulatory and anti-inflammatory properties, which combined, may accelerate healing. Our main objective is to summarize the clinical trials we found, highlighting the efficacy rates of this therapy and the main limitations we found in the analysis of the results. We conclude that, in perianal fistulas refractory to conventional therapies, the treatment with adipose tissue-derived mesenchymal cells is safe with promising results that may change the current paradigm of Crohn's related fistula treatment.Sociedade Brasileira de Coloproctologia2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000300240Journal of Coloproctology (Rio de Janeiro) v.38 n.3 2018reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2018.03.004info:eu-repo/semantics/openAccessTavares,Mónica Maria RamosBarbosa,Laura Elisabete Ribeiroeng2018-09-05T00:00:00Zoai:scielo:S2237-93632018000300240Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2018-09-05T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
title |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
spellingShingle |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae Tavares,Mónica Maria Ramos Crohn's disease Fistula Adipose tissue Stem cell |
title_short |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
title_full |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
title_fullStr |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
title_full_unstemmed |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
title_sort |
Adipose tissue-derived stem cells: a new approach to the treatment of Crohn's disease-associated perianal fistulae |
author |
Tavares,Mónica Maria Ramos |
author_facet |
Tavares,Mónica Maria Ramos Barbosa,Laura Elisabete Ribeiro |
author_role |
author |
author2 |
Barbosa,Laura Elisabete Ribeiro |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Tavares,Mónica Maria Ramos Barbosa,Laura Elisabete Ribeiro |
dc.subject.por.fl_str_mv |
Crohn's disease Fistula Adipose tissue Stem cell |
topic |
Crohn's disease Fistula Adipose tissue Stem cell |
description |
ABSTRACT Crohn's disease has an ever-increasing prevalence and incidence, with about 20% of patients developing perianal fistula with significant impact on their quality of life. Despite the medical and surgical treatments currently used, Crohn's-related fistula treatment continues to pose a challenge due to the low rates of efficacy associated with high recurrence rates. Recent clinical trials have shown promising results regarding safety and efficacy of local treatment of this condition with the use of adipose tissue-derived mesenchymal stem cells. Besides being pluripotent and poorly immunogenic, they have immunomodulatory and anti-inflammatory properties, which combined, may accelerate healing. Our main objective is to summarize the clinical trials we found, highlighting the efficacy rates of this therapy and the main limitations we found in the analysis of the results. We conclude that, in perianal fistulas refractory to conventional therapies, the treatment with adipose tissue-derived mesenchymal cells is safe with promising results that may change the current paradigm of Crohn's related fistula treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000300240 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000300240 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2018.03.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.38 n.3 2018 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
_version_ |
1752126478329315328 |