Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000400283 |
Resumo: | ABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton. |
id |
SBCP-1_4afbde22cfd96dfb1bdeac4f407586e5 |
---|---|
oai_identifier_str |
oai:scielo:S2237-93632018000400283 |
network_acronym_str |
SBCP-1 |
network_name_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository_id_str |
|
spelling |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extractRatsRectal fistulaPhytotherapyAloeTherapyABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton.Sociedade Brasileira de Coloproctologia2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000400283Journal of Coloproctology (Rio de Janeiro) v.38 n.4 2018reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2018.05.009info:eu-repo/semantics/openAccessComparin,Bruno CabralSantos,Carlos Henrique Marques dosDourado,Doroty MesquitaReichel,Pâmela Micaela GomesPaola,Roberta Silva dePontes,Elenir Rose Jardim Curyeng2018-11-23T00:00:00Zoai:scielo:S2237-93632018000400283Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2018-11-23T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
title |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
spellingShingle |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract Comparin,Bruno Cabral Rats Rectal fistula Phytotherapy Aloe Therapy |
title_short |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
title_full |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
title_fullStr |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
title_full_unstemmed |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
title_sort |
Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract |
author |
Comparin,Bruno Cabral |
author_facet |
Comparin,Bruno Cabral Santos,Carlos Henrique Marques dos Dourado,Doroty Mesquita Reichel,Pâmela Micaela Gomes Paola,Roberta Silva de Pontes,Elenir Rose Jardim Cury |
author_role |
author |
author2 |
Santos,Carlos Henrique Marques dos Dourado,Doroty Mesquita Reichel,Pâmela Micaela Gomes Paola,Roberta Silva de Pontes,Elenir Rose Jardim Cury |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Comparin,Bruno Cabral Santos,Carlos Henrique Marques dos Dourado,Doroty Mesquita Reichel,Pâmela Micaela Gomes Paola,Roberta Silva de Pontes,Elenir Rose Jardim Cury |
dc.subject.por.fl_str_mv |
Rats Rectal fistula Phytotherapy Aloe Therapy |
topic |
Rats Rectal fistula Phytotherapy Aloe Therapy |
description |
ABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000400283 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000400283 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2018.05.009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.38 n.4 2018 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
_version_ |
1752126478339801088 |