Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000200134 |
Resumo: | ABSTRACT Background: Colon cancer (CC) one of the most common oncological disease in World. Up to 30% patients in Russia have metastatic CC at first visiting to oncologist. The treatment results still controversial. Nowadays, minimally invasive laparoscopic precision technique allowed extending the indication for cytoreductive surgery even in patients with severe comorbidities. Materials and methods: 89 patients with colon cancer (T1-4a) and curable synchronous distant metastases include in study. All patients underwent cytoreductive surgery with primary tumor resection. In study group (44) we performed laparoscopic surgery, in main group (45) - open surgery procedure. The groups were similar by sex, age, tumor localization and histological structure, comorbidities. Results: R0 resection performed 27% patients. The average number of lymph node removal was similar 13 and 12 respectively. Average operation time was significantly longer in study group 210 vs 120 min. In study group blood loss was lower: 300 mL vs 1200 mL. Postoperative patient recovery shorter after laparoscopic surgery (p < 0.05): time to activation 2.2 vs 3.9 days; time to first peristalsis - 1.8 vs 4.5 days; first bowel movement - 3.4 vs 4.8 days; first food taken - 2.9 vs 3.9 days. Shorter time of analgesics intake - 2.3 vs 4.4 days, p < 0.05. Hospital stay shorter: 9.3 vs 13.4 days, p = 0.05. Time to start chemotherapy reduced since 27.5 to 14.7 days, p < 0.05. Postoperative complications lower in study group: 6.8 vs 17.8%, p = 0.05. Kaplan-Meier 2-year overall survival were similar: 69.5% vs 61.6%, p = 0.96. Conclusion: Laparoscopic cytoreductive surgery for metastatic CC is safe, minimized surgical trauma and speed up patient recovery. |
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Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategyLaparoscopic surgery for colorectal cancerCytoreductive surgeryMetastatic colorectal cancerABSTRACT Background: Colon cancer (CC) one of the most common oncological disease in World. Up to 30% patients in Russia have metastatic CC at first visiting to oncologist. The treatment results still controversial. Nowadays, minimally invasive laparoscopic precision technique allowed extending the indication for cytoreductive surgery even in patients with severe comorbidities. Materials and methods: 89 patients with colon cancer (T1-4a) and curable synchronous distant metastases include in study. All patients underwent cytoreductive surgery with primary tumor resection. In study group (44) we performed laparoscopic surgery, in main group (45) - open surgery procedure. The groups were similar by sex, age, tumor localization and histological structure, comorbidities. Results: R0 resection performed 27% patients. The average number of lymph node removal was similar 13 and 12 respectively. Average operation time was significantly longer in study group 210 vs 120 min. In study group blood loss was lower: 300 mL vs 1200 mL. Postoperative patient recovery shorter after laparoscopic surgery (p < 0.05): time to activation 2.2 vs 3.9 days; time to first peristalsis - 1.8 vs 4.5 days; first bowel movement - 3.4 vs 4.8 days; first food taken - 2.9 vs 3.9 days. Shorter time of analgesics intake - 2.3 vs 4.4 days, p < 0.05. Hospital stay shorter: 9.3 vs 13.4 days, p = 0.05. Time to start chemotherapy reduced since 27.5 to 14.7 days, p < 0.05. Postoperative complications lower in study group: 6.8 vs 17.8%, p = 0.05. Kaplan-Meier 2-year overall survival were similar: 69.5% vs 61.6%, p = 0.96. Conclusion: Laparoscopic cytoreductive surgery for metastatic CC is safe, minimized surgical trauma and speed up patient recovery.Sociedade Brasileira de Coloproctologia2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000200134Journal of Coloproctology (Rio de Janeiro) v.37 n.2 2017reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2017.02.003info:eu-repo/semantics/openAccessAtroshchenko,AndreyKhatkov,IgorPozdnyakov,StepanDanilov,Mikhaileng2017-06-27T00:00:00Zoai:scielo:S2237-93632017000200134Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2017-06-27T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
title |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
spellingShingle |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy Atroshchenko,Andrey Laparoscopic surgery for colorectal cancer Cytoreductive surgery Metastatic colorectal cancer |
title_short |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
title_full |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
title_fullStr |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
title_full_unstemmed |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
title_sort |
Laparoscopic cytoreductive surgery for metastatic colon cancer - how to improve treatment strategy |
author |
Atroshchenko,Andrey |
author_facet |
Atroshchenko,Andrey Khatkov,Igor Pozdnyakov,Stepan Danilov,Mikhail |
author_role |
author |
author2 |
Khatkov,Igor Pozdnyakov,Stepan Danilov,Mikhail |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Atroshchenko,Andrey Khatkov,Igor Pozdnyakov,Stepan Danilov,Mikhail |
dc.subject.por.fl_str_mv |
Laparoscopic surgery for colorectal cancer Cytoreductive surgery Metastatic colorectal cancer |
topic |
Laparoscopic surgery for colorectal cancer Cytoreductive surgery Metastatic colorectal cancer |
description |
ABSTRACT Background: Colon cancer (CC) one of the most common oncological disease in World. Up to 30% patients in Russia have metastatic CC at first visiting to oncologist. The treatment results still controversial. Nowadays, minimally invasive laparoscopic precision technique allowed extending the indication for cytoreductive surgery even in patients with severe comorbidities. Materials and methods: 89 patients with colon cancer (T1-4a) and curable synchronous distant metastases include in study. All patients underwent cytoreductive surgery with primary tumor resection. In study group (44) we performed laparoscopic surgery, in main group (45) - open surgery procedure. The groups were similar by sex, age, tumor localization and histological structure, comorbidities. Results: R0 resection performed 27% patients. The average number of lymph node removal was similar 13 and 12 respectively. Average operation time was significantly longer in study group 210 vs 120 min. In study group blood loss was lower: 300 mL vs 1200 mL. Postoperative patient recovery shorter after laparoscopic surgery (p < 0.05): time to activation 2.2 vs 3.9 days; time to first peristalsis - 1.8 vs 4.5 days; first bowel movement - 3.4 vs 4.8 days; first food taken - 2.9 vs 3.9 days. Shorter time of analgesics intake - 2.3 vs 4.4 days, p < 0.05. Hospital stay shorter: 9.3 vs 13.4 days, p = 0.05. Time to start chemotherapy reduced since 27.5 to 14.7 days, p < 0.05. Postoperative complications lower in study group: 6.8 vs 17.8%, p = 0.05. Kaplan-Meier 2-year overall survival were similar: 69.5% vs 61.6%, p = 0.96. Conclusion: Laparoscopic cytoreductive surgery for metastatic CC is safe, minimized surgical trauma and speed up patient recovery. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000200134 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000200134 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2017.02.003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.37 n.2 2017 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
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1752126477928759296 |