Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service

Detalhes bibliográficos
Autor(a) principal: Frasson,Murilo Zomer
Data de Publicação: 2016
Outros Autores: Kock,Kaiser S., Monteiro,Letícia F., Romagna,Jonas V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000400220
Resumo: ABSTRACT Among the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: Determine whether dissection ≥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability (p) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number ≥12 lymph nodes were dissected (p = 0.001) (Kruskal-Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic (p < 0.0001) or perineural invasion (p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection ≥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion.
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spelling Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral serviceColorectal neoplasmsLymph nodesLymph node excisionABSTRACT Among the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: Determine whether dissection ≥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability (p) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number ≥12 lymph nodes were dissected (p = 0.001) (Kruskal-Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic (p < 0.0001) or perineural invasion (p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection ≥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion.Sociedade Brasileira de Coloproctologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000400220Journal of Coloproctology (Rio de Janeiro) v.36 n.4 2016reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2016.06.004info:eu-repo/semantics/openAccessFrasson,Murilo ZomerKock,Kaiser S.Monteiro,Letícia F.Romagna,Jonas V.eng2016-12-15T00:00:00Zoai:scielo:S2237-93632016000400220Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2016-12-15T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false
dc.title.none.fl_str_mv Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
title Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
spellingShingle Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
Frasson,Murilo Zomer
Colorectal neoplasms
Lymph nodes
Lymph node excision
title_short Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
title_full Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
title_fullStr Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
title_full_unstemmed Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
title_sort Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
author Frasson,Murilo Zomer
author_facet Frasson,Murilo Zomer
Kock,Kaiser S.
Monteiro,Letícia F.
Romagna,Jonas V.
author_role author
author2 Kock,Kaiser S.
Monteiro,Letícia F.
Romagna,Jonas V.
author2_role author
author
author
dc.contributor.author.fl_str_mv Frasson,Murilo Zomer
Kock,Kaiser S.
Monteiro,Letícia F.
Romagna,Jonas V.
dc.subject.por.fl_str_mv Colorectal neoplasms
Lymph nodes
Lymph node excision
topic Colorectal neoplasms
Lymph nodes
Lymph node excision
description ABSTRACT Among the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: Determine whether dissection ≥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability (p) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number ≥12 lymph nodes were dissected (p = 0.001) (Kruskal-Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic (p < 0.0001) or perineural invasion (p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection ≥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1016/j.jcol.2016.06.004
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
dc.source.none.fl_str_mv Journal of Coloproctology (Rio de Janeiro) v.36 n.4 2016
reponame:Journal of Coloproctology (Rio de Janeiro. Online)
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instname_str Sociedade Brasileira de Coloproctologia (SBCP)
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reponame_str Journal of Coloproctology (Rio de Janeiro. Online)
collection Journal of Coloproctology (Rio de Janeiro. Online)
repository.name.fl_str_mv Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)
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