Adipose tissue mature stem cells in skin healing: a controlled randomized study

• Autor(a) principal: Martins,Pedro Djacir Escobar
• Data de Publicação: 2011
• Outros Autores: Uebel,Carlos Oscar, Machado,Denise Cantarelli, Silva,Jefferson Braga da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Cirurgia Plástica (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-51752011000300006
• topic: Stem cells; Wound healing; Abdomen/surgery

BACKGROUND: The differences between fetal and adult scars suggest the possibility of manipulating skin scarring outcomes. This study aimed to assess whether the use of adult stem cells from adipose tissue is beneficial to skin healing. METHODS: This was a randomized controlled study for which 18 patients were selected based on inclusion and exclusion criteria. The adult stem cells used were autologous and were extracted from infraumbilical adipose tissue prior to abdominoplasty. These cells were implanted into the surgical wound dermis in the suprapubic region before skin synthesis. The results were assessed blindly based on the Draaijers scale by three physicians and by the patients themselves in a self-assessment. Photometric assessment by digital photography was also performed. RESULTS: Among the 18 operated patients, considering the surgical result, 17 (94.4%) had excellent or good results and one (5.5%) had wound dehiscence, which was considered a bad result. Considering skin healing in the searched area, there was no statistically significant difference in the photometric evaluation; in both the self-assessment by the patients and the physicians' assessment, the results were significantly in favor of intervention with stem cells (P = 0.12 and P = 0.003, respectively). Consideration of all assessments (physicians, patients and photometric) found a statistically significant difference in favor of the implantation of adult stem cells from adipose tissue (P <0.001). CONCLUSIONS: Skin healing results after implantation of adult stem cells derived from adipose tissue were satisfactory.