Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100932 |
Resumo: | Abstract To evaluate the effectiveness of regulating insulin sensitivity via the insulin receptor substrate-1 of Zingiber striolatum bud extract in C57BL/KsJ-db/db mice. The C57BL mice were randomly divided into 5 groups (n=10), including normal control group, model group, metformin group, ZS-l (ZS low dose) group, and ZS-h (ZS high dose) group. The body weight and blood glucose were determined weekly. The oral glucose tolerance test, plasma insulin and biochemical parameters, pancreas histopathology, and the expression of insulin receptor substrate-1 were assayed at the end of experimental point. The results showed that Z. striolatum bud extract can significantly decrease the fasting blood glucose and glycated hemoglobin levels and insulin resistance (HOMA-IR) in C57BL mice. Western blot analysis demonstrated Z. striolatum bud extract could regulate the insulin sensitivity by upregulating the express of phospho-insulin receptor substrate-1. In conclusion, Z. striolatum bud extract could prevent the progression of diabetes and pancreatic fibrosis in C57BL mice. |
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Food Science and Technology (Campinas) |
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Hypoglycemic effect of Zingiber striolatum bud extract in db/db miceZingiber striolatuminsulin receptor substrate-1phospho-insulin receptor substrate 1insulin resistancetype 2 diabetes mellitusAbstract To evaluate the effectiveness of regulating insulin sensitivity via the insulin receptor substrate-1 of Zingiber striolatum bud extract in C57BL/KsJ-db/db mice. The C57BL mice were randomly divided into 5 groups (n=10), including normal control group, model group, metformin group, ZS-l (ZS low dose) group, and ZS-h (ZS high dose) group. The body weight and blood glucose were determined weekly. The oral glucose tolerance test, plasma insulin and biochemical parameters, pancreas histopathology, and the expression of insulin receptor substrate-1 were assayed at the end of experimental point. The results showed that Z. striolatum bud extract can significantly decrease the fasting blood glucose and glycated hemoglobin levels and insulin resistance (HOMA-IR) in C57BL mice. Western blot analysis demonstrated Z. striolatum bud extract could regulate the insulin sensitivity by upregulating the express of phospho-insulin receptor substrate-1. In conclusion, Z. striolatum bud extract could prevent the progression of diabetes and pancreatic fibrosis in C57BL mice.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100932Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.114321info:eu-repo/semantics/openAccessTAN,DaopengCUI,JinguoQIN,LinWANG,YuheHE,YuqiCHEN,LiSHE,Xiangqianeng2022-03-10T00:00:00Zoai:scielo:S0101-20612022000100932Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-03-10T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
title |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
spellingShingle |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice TAN,Daopeng Zingiber striolatum insulin receptor substrate-1 phospho-insulin receptor substrate 1 insulin resistance type 2 diabetes mellitus |
title_short |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
title_full |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
title_fullStr |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
title_full_unstemmed |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
title_sort |
Hypoglycemic effect of Zingiber striolatum bud extract in db/db mice |
author |
TAN,Daopeng |
author_facet |
TAN,Daopeng CUI,Jinguo QIN,Lin WANG,Yuhe HE,Yuqi CHEN,Li SHE,Xiangqian |
author_role |
author |
author2 |
CUI,Jinguo QIN,Lin WANG,Yuhe HE,Yuqi CHEN,Li SHE,Xiangqian |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
TAN,Daopeng CUI,Jinguo QIN,Lin WANG,Yuhe HE,Yuqi CHEN,Li SHE,Xiangqian |
dc.subject.por.fl_str_mv |
Zingiber striolatum insulin receptor substrate-1 phospho-insulin receptor substrate 1 insulin resistance type 2 diabetes mellitus |
topic |
Zingiber striolatum insulin receptor substrate-1 phospho-insulin receptor substrate 1 insulin resistance type 2 diabetes mellitus |
description |
Abstract To evaluate the effectiveness of regulating insulin sensitivity via the insulin receptor substrate-1 of Zingiber striolatum bud extract in C57BL/KsJ-db/db mice. The C57BL mice were randomly divided into 5 groups (n=10), including normal control group, model group, metformin group, ZS-l (ZS low dose) group, and ZS-h (ZS high dose) group. The body weight and blood glucose were determined weekly. The oral glucose tolerance test, plasma insulin and biochemical parameters, pancreas histopathology, and the expression of insulin receptor substrate-1 were assayed at the end of experimental point. The results showed that Z. striolatum bud extract can significantly decrease the fasting blood glucose and glycated hemoglobin levels and insulin resistance (HOMA-IR) in C57BL mice. Western blot analysis demonstrated Z. striolatum bud extract could regulate the insulin sensitivity by upregulating the express of phospho-insulin receptor substrate-1. In conclusion, Z. striolatum bud extract could prevent the progression of diabetes and pancreatic fibrosis in C57BL mice. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100932 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100932 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.114321 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.42 2022 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
_version_ |
1752126333649944576 |