Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer

Detalhes bibliográficos
Autor(a) principal: BEN,Wei
Data de Publicação: 2022
Outros Autores: ZHANG,Guangmei, ZHAO,Lu, LIANG,Tian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100817
Resumo: Abstract Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies including cervical cancer and are involved in tumor development and oncogenesis. Here, we found that circABCB10 was higher in 58 cervical cancer tissue sample than that in the adjacent normal tissues. Higher circABCB10 expression significantly associated with advanced the International Federation of Gynecology and Obstetrics (FIGO) stage and greater lymphatic invasion, and worse survival time in cervical cancer patients. Function assays showed that circABCB10 silencing inhibited cell proliferation, migration and invasion capacities. Moreover, we demonstrated that inhibition of circABCB10 upregulated epithelial-mesenchymal transition (EMT)-related proteins E-cadherin expression and downregulated the Vimentin expression, which suggested that affected EMT signaling pathway in cervical cancer. Thus, the circABCB10 may contribute to the development of cervical cancer by affecting epithelial-mesenchymal transition signaling pathways.
id SBCTA-1_33825b6e40f2bdaffbff39e1fd07fa30
oai_identifier_str oai:scielo:S0101-20612022000100817
network_acronym_str SBCTA-1
network_name_str Food Science and Technology (Campinas)
repository_id_str
spelling Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancercervical cancercircular RNAcircABCB10cell proliferationcell invasionAbstract Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies including cervical cancer and are involved in tumor development and oncogenesis. Here, we found that circABCB10 was higher in 58 cervical cancer tissue sample than that in the adjacent normal tissues. Higher circABCB10 expression significantly associated with advanced the International Federation of Gynecology and Obstetrics (FIGO) stage and greater lymphatic invasion, and worse survival time in cervical cancer patients. Function assays showed that circABCB10 silencing inhibited cell proliferation, migration and invasion capacities. Moreover, we demonstrated that inhibition of circABCB10 upregulated epithelial-mesenchymal transition (EMT)-related proteins E-cadherin expression and downregulated the Vimentin expression, which suggested that affected EMT signaling pathway in cervical cancer. Thus, the circABCB10 may contribute to the development of cervical cancer by affecting epithelial-mesenchymal transition signaling pathways.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100817Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.54521info:eu-repo/semantics/openAccessBEN,WeiZHANG,GuangmeiZHAO,LuLIANG,Tianeng2022-02-23T00:00:00Zoai:scielo:S0101-20612022000100817Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-02-23T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
title Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
spellingShingle Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
BEN,Wei
cervical cancer
circular RNA
circABCB10
cell proliferation
cell invasion
title_short Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
title_full Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
title_fullStr Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
title_full_unstemmed Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
title_sort Circrna ABCB10 promotes cell proliferation and invasion by affecting emt signaling pathway in cervical cancer
author BEN,Wei
author_facet BEN,Wei
ZHANG,Guangmei
ZHAO,Lu
LIANG,Tian
author_role author
author2 ZHANG,Guangmei
ZHAO,Lu
LIANG,Tian
author2_role author
author
author
dc.contributor.author.fl_str_mv BEN,Wei
ZHANG,Guangmei
ZHAO,Lu
LIANG,Tian
dc.subject.por.fl_str_mv cervical cancer
circular RNA
circABCB10
cell proliferation
cell invasion
topic cervical cancer
circular RNA
circABCB10
cell proliferation
cell invasion
description Abstract Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies including cervical cancer and are involved in tumor development and oncogenesis. Here, we found that circABCB10 was higher in 58 cervical cancer tissue sample than that in the adjacent normal tissues. Higher circABCB10 expression significantly associated with advanced the International Federation of Gynecology and Obstetrics (FIGO) stage and greater lymphatic invasion, and worse survival time in cervical cancer patients. Function assays showed that circABCB10 silencing inhibited cell proliferation, migration and invasion capacities. Moreover, we demonstrated that inhibition of circABCB10 upregulated epithelial-mesenchymal transition (EMT)-related proteins E-cadherin expression and downregulated the Vimentin expression, which suggested that affected EMT signaling pathway in cervical cancer. Thus, the circABCB10 may contribute to the development of cervical cancer by affecting epithelial-mesenchymal transition signaling pathways.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100817
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100817
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.54521
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.42 2022
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
_version_ 1752126333195911168

Registros relacionados