Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612023000100402 |
Resumo: | Abstract The present study was designed to evaluate functional potential of Aloe vera juice against (CCl4 induced) hepatotoxicity using animal model. Biochemical analyses including liver, renal enzymes, bone biomarkers and lipid profile were conducted after 4 weeks of oral Aloe vera juice administration. Liver enzymes, AST, ALP and total bilirubin were reduced up to 15-7%, 60-32.52% and 29-48%, respectively in Aloe vera juice treated rats i.e., 10 mL/kg and 20 mL/kg doses. Reduction in serum cholesterol (8%), LDL (12%) and triglycerides (15%) were observed. Urea was significantly reduced up to 11% which further reduced up to 30% at higher dose. Increased content of serum proteins (23-50%) and albumin (40-116%) were found at the different doses. Vitamin D was found maximum in G4 i.e., 38.63 mg/dL as compared to lowest i.e., 5.12 mg/dL in G2, similarly improvement in calcium i.e., 11-22% was observed in G3 and G4. The serum oxidative stress markers indicated raised superoxide dismutase (9%), glutathione (15%), catalase (9%) and reduced lipid peroxidation 78% at higher concentration of Aloe vera juice consumption. In addition, histological evaluation also depicted positive impact on hepatic and renal portfolio in all treated rats. All of the findings enlighten the potential of Aloe vera juice as a functional beverage. |
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Food Science and Technology (Campinas) |
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Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal modelAloe juicefunctional beveragehepatotoxicityoxidative stressAbstract The present study was designed to evaluate functional potential of Aloe vera juice against (CCl4 induced) hepatotoxicity using animal model. Biochemical analyses including liver, renal enzymes, bone biomarkers and lipid profile were conducted after 4 weeks of oral Aloe vera juice administration. Liver enzymes, AST, ALP and total bilirubin were reduced up to 15-7%, 60-32.52% and 29-48%, respectively in Aloe vera juice treated rats i.e., 10 mL/kg and 20 mL/kg doses. Reduction in serum cholesterol (8%), LDL (12%) and triglycerides (15%) were observed. Urea was significantly reduced up to 11% which further reduced up to 30% at higher dose. Increased content of serum proteins (23-50%) and albumin (40-116%) were found at the different doses. Vitamin D was found maximum in G4 i.e., 38.63 mg/dL as compared to lowest i.e., 5.12 mg/dL in G2, similarly improvement in calcium i.e., 11-22% was observed in G3 and G4. The serum oxidative stress markers indicated raised superoxide dismutase (9%), glutathione (15%), catalase (9%) and reduced lipid peroxidation 78% at higher concentration of Aloe vera juice consumption. In addition, histological evaluation also depicted positive impact on hepatic and renal portfolio in all treated rats. All of the findings enlighten the potential of Aloe vera juice as a functional beverage.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2023-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612023000100402Food Science and Technology v.43 2023reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.110321info:eu-repo/semantics/openAccessAHMAD,MateenALI,Shinawar WaseemHAMEED,AneelaAMIR,MamoonaASHRAF,JawadAfzal,Muhammad InamUMER,MuhammadALSAGABY,Suliman A.AWAIS,MuhammadIMRAN,MuhammadIQBAL,SanaullahAHMED,AftabRIAZ,Muhammadeng2022-10-17T00:00:00Zoai:scielo:S0101-20612023000100402Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-10-17T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
title |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
spellingShingle |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model AHMAD,Mateen Aloe juice functional beverage hepatotoxicity oxidative stress |
title_short |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
title_full |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
title_fullStr |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
title_full_unstemmed |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
title_sort |
Functional potential of Aloe vera juice against CCl4 induced hepatotoxicity in animal model |
author |
AHMAD,Mateen |
author_facet |
AHMAD,Mateen ALI,Shinawar Waseem HAMEED,Aneela AMIR,Mamoona ASHRAF,Jawad Afzal,Muhammad Inam UMER,Muhammad ALSAGABY,Suliman A. AWAIS,Muhammad IMRAN,Muhammad IQBAL,Sanaullah AHMED,Aftab RIAZ,Muhammad |
author_role |
author |
author2 |
ALI,Shinawar Waseem HAMEED,Aneela AMIR,Mamoona ASHRAF,Jawad Afzal,Muhammad Inam UMER,Muhammad ALSAGABY,Suliman A. AWAIS,Muhammad IMRAN,Muhammad IQBAL,Sanaullah AHMED,Aftab RIAZ,Muhammad |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
AHMAD,Mateen ALI,Shinawar Waseem HAMEED,Aneela AMIR,Mamoona ASHRAF,Jawad Afzal,Muhammad Inam UMER,Muhammad ALSAGABY,Suliman A. AWAIS,Muhammad IMRAN,Muhammad IQBAL,Sanaullah AHMED,Aftab RIAZ,Muhammad |
dc.subject.por.fl_str_mv |
Aloe juice functional beverage hepatotoxicity oxidative stress |
topic |
Aloe juice functional beverage hepatotoxicity oxidative stress |
description |
Abstract The present study was designed to evaluate functional potential of Aloe vera juice against (CCl4 induced) hepatotoxicity using animal model. Biochemical analyses including liver, renal enzymes, bone biomarkers and lipid profile were conducted after 4 weeks of oral Aloe vera juice administration. Liver enzymes, AST, ALP and total bilirubin were reduced up to 15-7%, 60-32.52% and 29-48%, respectively in Aloe vera juice treated rats i.e., 10 mL/kg and 20 mL/kg doses. Reduction in serum cholesterol (8%), LDL (12%) and triglycerides (15%) were observed. Urea was significantly reduced up to 11% which further reduced up to 30% at higher dose. Increased content of serum proteins (23-50%) and albumin (40-116%) were found at the different doses. Vitamin D was found maximum in G4 i.e., 38.63 mg/dL as compared to lowest i.e., 5.12 mg/dL in G2, similarly improvement in calcium i.e., 11-22% was observed in G3 and G4. The serum oxidative stress markers indicated raised superoxide dismutase (9%), glutathione (15%), catalase (9%) and reduced lipid peroxidation 78% at higher concentration of Aloe vera juice consumption. In addition, histological evaluation also depicted positive impact on hepatic and renal portfolio in all treated rats. All of the findings enlighten the potential of Aloe vera juice as a functional beverage. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612023000100402 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612023000100402 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.110321 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.43 2023 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
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1752126336061669376 |