Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents

Detalhes bibliográficos
Autor(a) principal: Düsman,Elisângela
Data de Publicação: 2013
Outros Autores: Berti,Alessandra Paim, Soares,Lilian Capelari, Vicentini,Veronica Elisa Pimenta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000100018
Resumo: Due to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic. However, the Cola soft drink proved mutagenic in this experiment treatment time. Therefore, this study serves as a warning about the consumption of Cola-flavored soft drink and for the need for further subchronic and chronic studies on soft drinks in order to evaluate the long term mutagenic and cytotoxic effects of these substances.
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spelling Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodentschromosomal aberrationsoft drinksWistar ratsDue to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic. However, the Cola soft drink proved mutagenic in this experiment treatment time. Therefore, this study serves as a warning about the consumption of Cola-flavored soft drink and for the need for further subchronic and chronic studies on soft drinks in order to evaluate the long term mutagenic and cytotoxic effects of these substances.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000100018Food Science and Technology v.33 n.1 2013reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/S0101-20612013005000011info:eu-repo/semantics/openAccessDüsman,ElisângelaBerti,Alessandra PaimSoares,Lilian CapelariVicentini,Veronica Elisa Pimentaeng2013-04-09T00:00:00Zoai:scielo:S0101-20612013000100018Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2013-04-09T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
title Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
spellingShingle Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
Düsman,Elisângela
chromosomal aberration
soft drinks
Wistar rats
title_short Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
title_full Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
title_fullStr Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
title_full_unstemmed Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
title_sort Cytotoxicity and mutagenicity of cola and grape flavored soft drinks in bone marrow cells of rodents
author Düsman,Elisângela
author_facet Düsman,Elisângela
Berti,Alessandra Paim
Soares,Lilian Capelari
Vicentini,Veronica Elisa Pimenta
author_role author
author2 Berti,Alessandra Paim
Soares,Lilian Capelari
Vicentini,Veronica Elisa Pimenta
author2_role author
author
author
dc.contributor.author.fl_str_mv Düsman,Elisângela
Berti,Alessandra Paim
Soares,Lilian Capelari
Vicentini,Veronica Elisa Pimenta
dc.subject.por.fl_str_mv chromosomal aberration
soft drinks
Wistar rats
topic chromosomal aberration
soft drinks
Wistar rats
description Due to the large consumption of soft drinks in Brazil and worldwide in recent years and considering that some of the components present in their composition pose potential risks to human health, the aim of this study was to evaluate the cytotoxic and mutagenic potential of specific cola and grape-flavored soft drink brands. Bone marrow cells of Wistar rats were initially treated by gavage with one single dose of Cola or Grape soft drink, which was next offered ad libitum (instead of water) for 24 hours. A negative control treatment was performed by administering one single dose of water and a positive control administering cyclophosphamide intraperitoneally. Statistical analysis showed that the Cola and Grape soft drinks studied were not cytotoxic. However, the Cola soft drink proved mutagenic in this experiment treatment time. Therefore, this study serves as a warning about the consumption of Cola-flavored soft drink and for the need for further subchronic and chronic studies on soft drinks in order to evaluate the long term mutagenic and cytotoxic effects of these substances.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000100018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612013000100018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0101-20612013005000011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.33 n.1 2013
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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