A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China

Detalhes bibliográficos
Autor(a) principal: YAN,Li-ping
Data de Publicação: 2021
Outros Autores: LUO,Wen-jun, XIAO,Xiao-hui, LUO,Tian-wen, LIU,Hua
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000300564
Resumo: Abstract For different populations, the association studies between the beta-2 adrenergic receptor (ADRB2) Arg16Gly mutation and asthma are conflict. This study was designated to evaluate ADRB2 Arg16Gly polymorphism and asthma in Chinese population. Systemic assessment was performed based on the data from PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) up to January 2019. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using STATA software. This meta-analysis included 6143 asthma patients and 5919 healthy persons from 34 studies. Overall, ADRB2 Arg16Gly polymorphism showed no significant influence on asthma in China. However, subgroup analyses according to geographic areas, age group and HWE in controls, only found a borderline significant effect for southern Chinese under the homozygotes genetic model (OR = 0.82, 95%CI = 0.68-1.00, P = 0.046). This meta-analysis suggests that ADRB2 Arg16Gly polymorphism is not be related to the development of asthma in China.
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spelling A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in ChinaADRB2 Arg16Glypolymorphismasthmameta-analysisChineseAbstract For different populations, the association studies between the beta-2 adrenergic receptor (ADRB2) Arg16Gly mutation and asthma are conflict. This study was designated to evaluate ADRB2 Arg16Gly polymorphism and asthma in Chinese population. Systemic assessment was performed based on the data from PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) up to January 2019. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using STATA software. This meta-analysis included 6143 asthma patients and 5919 healthy persons from 34 studies. Overall, ADRB2 Arg16Gly polymorphism showed no significant influence on asthma in China. However, subgroup analyses according to geographic areas, age group and HWE in controls, only found a borderline significant effect for southern Chinese under the homozygotes genetic model (OR = 0.82, 95%CI = 0.68-1.00, P = 0.046). This meta-analysis suggests that ADRB2 Arg16Gly polymorphism is not be related to the development of asthma in China.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2021-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000300564Food Science and Technology v.41 n.3 2021reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.18520info:eu-repo/semantics/openAccessYAN,Li-pingLUO,Wen-junXIAO,Xiao-huiLUO,Tian-wenLIU,Huaeng2021-07-23T00:00:00Zoai:scielo:S0101-20612021000300564Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2021-07-23T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
title A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
spellingShingle A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
YAN,Li-ping
ADRB2 Arg16Gly
polymorphism
asthma
meta-analysis
Chinese
title_short A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
title_full A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
title_fullStr A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
title_full_unstemmed A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
title_sort A meta-analysis: association between Beta-2 adrenergic receptor Arg16Gly polymorphism and asthma in China
author YAN,Li-ping
author_facet YAN,Li-ping
LUO,Wen-jun
XIAO,Xiao-hui
LUO,Tian-wen
LIU,Hua
author_role author
author2 LUO,Wen-jun
XIAO,Xiao-hui
LUO,Tian-wen
LIU,Hua
author2_role author
author
author
author
dc.contributor.author.fl_str_mv YAN,Li-ping
LUO,Wen-jun
XIAO,Xiao-hui
LUO,Tian-wen
LIU,Hua
dc.subject.por.fl_str_mv ADRB2 Arg16Gly
polymorphism
asthma
meta-analysis
Chinese
topic ADRB2 Arg16Gly
polymorphism
asthma
meta-analysis
Chinese
description Abstract For different populations, the association studies between the beta-2 adrenergic receptor (ADRB2) Arg16Gly mutation and asthma are conflict. This study was designated to evaluate ADRB2 Arg16Gly polymorphism and asthma in Chinese population. Systemic assessment was performed based on the data from PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) up to January 2019. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using STATA software. This meta-analysis included 6143 asthma patients and 5919 healthy persons from 34 studies. Overall, ADRB2 Arg16Gly polymorphism showed no significant influence on asthma in China. However, subgroup analyses according to geographic areas, age group and HWE in controls, only found a borderline significant effect for southern Chinese under the homozygotes genetic model (OR = 0.82, 95%CI = 0.68-1.00, P = 0.046). This meta-analysis suggests that ADRB2 Arg16Gly polymorphism is not be related to the development of asthma in China.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000300564
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000300564
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.18520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.41 n.3 2021
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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