Studies on phytosterol acetate esters and phytosterols liposomes
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000401062 |
Resumo: | Abstract Phytosterols (PS) and phytosterol esters have been widely used in the food and health product industries as cholesterol-lowering agents. In order to improve theirs dispersity and bioavailability in low lipid media, PS and phytosterol acetate ester (PAE) were embedded into liposomes in the study. The effects of different PAE or PS concentrations on liposome properties were determined and interactions between PAE or PS and phospholipids were also explored. PAE and PS can be well embedded in liposomes, and the encapsulation rate was more than 90%. Compared to SPC liposomes, no significant difference (P > 0.05) in particle size (60 nm) and zeta potential (-15 mV) were observed between liposomes with PAE or PS. Liposomes were spherical, with smooth surfaces and uniform size distributions. The results of X-ray powder diffractometry (XRD) revealed that PAE and PS were amorphously embedded in liposomes. The results from the Fourier-transform infrared (FTIR) and Differential scanning calorimeter (DSC) analysis indicated that PAE or PS changed the structure of the lipid membrane by interacting with phospholipids in the liposomes. Low doses of PAE had a stabilizing effect on the liposome membrane structure. |
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Studies on phytosterol acetate esters and phytosterols liposomesphytosterol acetate estersphytosterolsliposomeeffectpropertiesAbstract Phytosterols (PS) and phytosterol esters have been widely used in the food and health product industries as cholesterol-lowering agents. In order to improve theirs dispersity and bioavailability in low lipid media, PS and phytosterol acetate ester (PAE) were embedded into liposomes in the study. The effects of different PAE or PS concentrations on liposome properties were determined and interactions between PAE or PS and phospholipids were also explored. PAE and PS can be well embedded in liposomes, and the encapsulation rate was more than 90%. Compared to SPC liposomes, no significant difference (P > 0.05) in particle size (60 nm) and zeta potential (-15 mV) were observed between liposomes with PAE or PS. Liposomes were spherical, with smooth surfaces and uniform size distributions. The results of X-ray powder diffractometry (XRD) revealed that PAE and PS were amorphously embedded in liposomes. The results from the Fourier-transform infrared (FTIR) and Differential scanning calorimeter (DSC) analysis indicated that PAE or PS changed the structure of the lipid membrane by interacting with phospholipids in the liposomes. Low doses of PAE had a stabilizing effect on the liposome membrane structure.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2021-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000401062Food Science and Technology v.41 n.4 2021reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.19221info:eu-repo/semantics/openAccessHOU,LifenSUN,XiangyangPAN,LiWANG,HongyanGU,Kereneng2021-12-10T00:00:00Zoai:scielo:S0101-20612021000401062Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2021-12-10T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
Studies on phytosterol acetate esters and phytosterols liposomes |
title |
Studies on phytosterol acetate esters and phytosterols liposomes |
spellingShingle |
Studies on phytosterol acetate esters and phytosterols liposomes HOU,Lifen phytosterol acetate esters phytosterols liposome effect properties |
title_short |
Studies on phytosterol acetate esters and phytosterols liposomes |
title_full |
Studies on phytosterol acetate esters and phytosterols liposomes |
title_fullStr |
Studies on phytosterol acetate esters and phytosterols liposomes |
title_full_unstemmed |
Studies on phytosterol acetate esters and phytosterols liposomes |
title_sort |
Studies on phytosterol acetate esters and phytosterols liposomes |
author |
HOU,Lifen |
author_facet |
HOU,Lifen SUN,Xiangyang PAN,Li WANG,Hongyan GU,Keren |
author_role |
author |
author2 |
SUN,Xiangyang PAN,Li WANG,Hongyan GU,Keren |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
HOU,Lifen SUN,Xiangyang PAN,Li WANG,Hongyan GU,Keren |
dc.subject.por.fl_str_mv |
phytosterol acetate esters phytosterols liposome effect properties |
topic |
phytosterol acetate esters phytosterols liposome effect properties |
description |
Abstract Phytosterols (PS) and phytosterol esters have been widely used in the food and health product industries as cholesterol-lowering agents. In order to improve theirs dispersity and bioavailability in low lipid media, PS and phytosterol acetate ester (PAE) were embedded into liposomes in the study. The effects of different PAE or PS concentrations on liposome properties were determined and interactions between PAE or PS and phospholipids were also explored. PAE and PS can be well embedded in liposomes, and the encapsulation rate was more than 90%. Compared to SPC liposomes, no significant difference (P > 0.05) in particle size (60 nm) and zeta potential (-15 mV) were observed between liposomes with PAE or PS. Liposomes were spherical, with smooth surfaces and uniform size distributions. The results of X-ray powder diffractometry (XRD) revealed that PAE and PS were amorphously embedded in liposomes. The results from the Fourier-transform infrared (FTIR) and Differential scanning calorimeter (DSC) analysis indicated that PAE or PS changed the structure of the lipid membrane by interacting with phospholipids in the liposomes. Low doses of PAE had a stabilizing effect on the liposome membrane structure. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000401062 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000401062 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.19221 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.41 n.4 2021 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
_version_ |
1752126329842565120 |