Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria

Detalhes bibliográficos
Autor(a) principal: JIANG,Huichuan
Data de Publicação: 2021
Outros Autores: YANG,Jing, FAN,Yanling, LIU,Yongping
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200482
Resumo: Abstract Dried unripe raspberries (Rubus chingii), a kind of Chinese herbal medicine, have been used for many years in China. They were prepared as unpurified raspberry extract (URE) by ethanol extraction, and purified raspberry extract (PRE) by macroporous resin. Synergistic effects between the URE (or the PRE) and ampicillin, erythromycin, tetracycline or streptomycin against Escherichia coli, Staphylococcus aureus and Salmonella enterica were carried out using checkerboard microdilution and time-kill curves, respectively. The results showed that all pairwise combinations revealed synergistic effects, with 0.10 ≤ fractional inhibitory concentration index ≤ 0.50 and more than 2 × log10 reduction in colony-forming units/mL. In particular, the erythromycin concentration in the combinations was reduced to 1/50-1/100 of its dose alone while retaining its effectiveness against S. aureus and E. coli. The synergistic effects of raspberry extracts and four antibiotics against three bacteria were related to the abundance of polyphenols in the extracts, especially ellagic acid. The extracts may be a dietary supplement and/or natural antimicrobials.
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spelling Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteriaantibioticsellagic acidnatural antimicrobialsraspberry extractssynergistic effectsAbstract Dried unripe raspberries (Rubus chingii), a kind of Chinese herbal medicine, have been used for many years in China. They were prepared as unpurified raspberry extract (URE) by ethanol extraction, and purified raspberry extract (PRE) by macroporous resin. Synergistic effects between the URE (or the PRE) and ampicillin, erythromycin, tetracycline or streptomycin against Escherichia coli, Staphylococcus aureus and Salmonella enterica were carried out using checkerboard microdilution and time-kill curves, respectively. The results showed that all pairwise combinations revealed synergistic effects, with 0.10 ≤ fractional inhibitory concentration index ≤ 0.50 and more than 2 × log10 reduction in colony-forming units/mL. In particular, the erythromycin concentration in the combinations was reduced to 1/50-1/100 of its dose alone while retaining its effectiveness against S. aureus and E. coli. The synergistic effects of raspberry extracts and four antibiotics against three bacteria were related to the abundance of polyphenols in the extracts, especially ellagic acid. The extracts may be a dietary supplement and/or natural antimicrobials.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200482Food Science and Technology v.41 n.2 2021reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.04020info:eu-repo/semantics/openAccessJIANG,HuichuanYANG,JingFAN,YanlingLIU,Yongpingeng2021-04-05T00:00:00Zoai:scielo:S0101-20612021000200482Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2021-04-05T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
title Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
spellingShingle Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
JIANG,Huichuan
antibiotics
ellagic acid
natural antimicrobials
raspberry extracts
synergistic effects
title_short Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
title_full Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
title_fullStr Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
title_full_unstemmed Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
title_sort Synergistic effects of unripe raspberry extracts (Rubus chingii) and antibiotics against three bacteria
author JIANG,Huichuan
author_facet JIANG,Huichuan
YANG,Jing
FAN,Yanling
LIU,Yongping
author_role author
author2 YANG,Jing
FAN,Yanling
LIU,Yongping
author2_role author
author
author
dc.contributor.author.fl_str_mv JIANG,Huichuan
YANG,Jing
FAN,Yanling
LIU,Yongping
dc.subject.por.fl_str_mv antibiotics
ellagic acid
natural antimicrobials
raspberry extracts
synergistic effects
topic antibiotics
ellagic acid
natural antimicrobials
raspberry extracts
synergistic effects
description Abstract Dried unripe raspberries (Rubus chingii), a kind of Chinese herbal medicine, have been used for many years in China. They were prepared as unpurified raspberry extract (URE) by ethanol extraction, and purified raspberry extract (PRE) by macroporous resin. Synergistic effects between the URE (or the PRE) and ampicillin, erythromycin, tetracycline or streptomycin against Escherichia coli, Staphylococcus aureus and Salmonella enterica were carried out using checkerboard microdilution and time-kill curves, respectively. The results showed that all pairwise combinations revealed synergistic effects, with 0.10 ≤ fractional inhibitory concentration index ≤ 0.50 and more than 2 × log10 reduction in colony-forming units/mL. In particular, the erythromycin concentration in the combinations was reduced to 1/50-1/100 of its dose alone while retaining its effectiveness against S. aureus and E. coli. The synergistic effects of raspberry extracts and four antibiotics against three bacteria were related to the abundance of polyphenols in the extracts, especially ellagic acid. The extracts may be a dietary supplement and/or natural antimicrobials.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200482
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021000200482
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.04020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.41 n.2 2021
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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