Tumor necrosis factor-alpha and the cytokine network in psoriasis

Detalhes bibliográficos
Autor(a) principal: Brotas,Arles Martins
Data de Publicação: 2012
Outros Autores: Cunha,José Marcos Tellas, Lago,Eduardo Henrique Jorge, Machado,Cristiane Chaves Nascentes, Carneiro,Sueli Coelho da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000500001
Resumo: New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans cells). This is a complex network due to redundancy, synergism and, sometimes, the antagonism of cytokines, which prevents full understanding of the pathogenesis of the disease. Currently, it seems premature to try to establish a main actor, but TNFalpha participates in all stages of psoriatic plaque development, as we shall see.
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spelling Tumor necrosis factor-alpha and the cytokine network in psoriasisCytokinesPsoriasisTumor necrosis factor-alphaNew molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans cells). This is a complex network due to redundancy, synergism and, sometimes, the antagonism of cytokines, which prevents full understanding of the pathogenesis of the disease. Currently, it seems premature to try to establish a main actor, but TNFalpha participates in all stages of psoriatic plaque development, as we shall see.Sociedade Brasileira de Dermatologia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000500001Anais Brasileiros de Dermatologia v.87 n.5 2012reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962012000500001info:eu-repo/semantics/openAccessBrotas,Arles MartinsCunha,José Marcos TellasLago,Eduardo Henrique JorgeMachado,Cristiane Chaves NascentesCarneiro,Sueli Coelho da Silvaeng2012-10-01T00:00:00Zoai:scielo:S0365-05962012000500001Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2012-10-01T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Tumor necrosis factor-alpha and the cytokine network in psoriasis
title Tumor necrosis factor-alpha and the cytokine network in psoriasis
spellingShingle Tumor necrosis factor-alpha and the cytokine network in psoriasis
Brotas,Arles Martins
Cytokines
Psoriasis
Tumor necrosis factor-alpha
title_short Tumor necrosis factor-alpha and the cytokine network in psoriasis
title_full Tumor necrosis factor-alpha and the cytokine network in psoriasis
title_fullStr Tumor necrosis factor-alpha and the cytokine network in psoriasis
title_full_unstemmed Tumor necrosis factor-alpha and the cytokine network in psoriasis
title_sort Tumor necrosis factor-alpha and the cytokine network in psoriasis
author Brotas,Arles Martins
author_facet Brotas,Arles Martins
Cunha,José Marcos Tellas
Lago,Eduardo Henrique Jorge
Machado,Cristiane Chaves Nascentes
Carneiro,Sueli Coelho da Silva
author_role author
author2 Cunha,José Marcos Tellas
Lago,Eduardo Henrique Jorge
Machado,Cristiane Chaves Nascentes
Carneiro,Sueli Coelho da Silva
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brotas,Arles Martins
Cunha,José Marcos Tellas
Lago,Eduardo Henrique Jorge
Machado,Cristiane Chaves Nascentes
Carneiro,Sueli Coelho da Silva
dc.subject.por.fl_str_mv Cytokines
Psoriasis
Tumor necrosis factor-alpha
topic Cytokines
Psoriasis
Tumor necrosis factor-alpha
description New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans cells). This is a complex network due to redundancy, synergism and, sometimes, the antagonism of cytokines, which prevents full understanding of the pathogenesis of the disease. Currently, it seems premature to try to establish a main actor, but TNFalpha participates in all stages of psoriatic plaque development, as we shall see.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000500001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000500001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0365-05962012000500001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.87 n.5 2012
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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