Multiple cutaneous melanomas associated with gastric and brain metastases

• Autor(a) principal: Grander,Lara Caroline
• Data de Publicação: 2016
• Outros Autores: Cabral,Fernanda, Lisboa,Alice Paixão, Vale,Gabrielle, Barcaui,Carlos Baptista, Maceira,Juan Manuel Pineiro
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Anais brasileiros de dermatologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016001100098
• topic: Cyclin-dependent kinase inhibitor protein; Cyclin-dependent Kinases; Melanoma; Neoplasm metastasis

Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.