Immunostaining study of cytokeratins in human hair follicle development,

• Main Author: Silva,Laura Maria Andrade
• Publication Date: 2020
• Other Authors: Hsieh,Ricardo, Lourenço,Silvia Vanessa, Valente,Neusa Yuriko Sakai, Paiva,Geise Rezende, Fernandes,Juliana Dumet
• Format: Article
• Language: eng
• Source: Anais brasileiros de dermatologia (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000300002
• topic: Hair follicle; Hair-specific; Keratins; Molecular; Pathology

Abstract Background: The hair follicle is a unique structure, one of the most dynamic structures in mammalians, which can reproduce in every new cycle all the mechanism involved in its fetal development. Although a lot of research has been made about the human hair follicle much less has been discovered about the importance of the cytokeratins (CKs) in its development. Objective: Study the immunohistochemical pattern of epithelial CKs during human hair follicle development. Methods: We performed an immunohistochemical study using fresh post-mortem skin biopsies of human fetuses between 4 and 25 weeks of gestational age to study the expression of cytokeratins (CKs): CK1, CK10, CK13, CK14, CK16 and CK20 during human hair follicle fetal development. Study limitations: Restrospective study with a good number of makers but with a small population. Results/conclusion: We found that, the CKs were expressed in an intermediate time during follicular development. The epithelial CKs (CK1, CK14, CK10, CK13) and the epithelial CKs with a proliferative character such as CK16 were expressed first, as markers of cellular maturation and follicular keratinization. At a later phase, CK20 was expressed in more developed primitive hair follicles as previously discussed in literature.