Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases

Detalhes bibliográficos
Autor(a) principal: Comparin,Cristiane
Data de Publicação: 2012
Outros Autores: Hans Filho,Günter, Takita,Luiz Carlos, Costa,Nayara de Castro Wiziack, Nascimento,Roberta Ayres Ferreira do, Nanni,Lidiane de Oliveira Costa
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000300022
Resumo: Stevens-Johnson's syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatoses, that lead to keratinocyte apoptosis induced by interactions between Fas (cell death receptor) and soluble Fas-ligand, present in serum of Stevens-Johnson's syndrome / toxic epidermal necrolysis patients. Anti-Fas antibodies in intravenous immunoglobulin (IVIG) would block the apoptosis cascade. Three cases of toxic epidermal necrolysis occurred in one male and two female patients, after use of allopurinol, leprosy multidrug therapy concomitant with dipyrone, and diclofenac. The cases were treated with intravenous immunoglobulin 2-3 mg/kg and prednisone 20-50 mg/day. The interruption of new lesions outbreak and reepithelization were extremely fast after the use of intravenous immunoglobulin, without adverse effects. Controlled studies are needed to confirm the efficacy of intravenous immunoglobulin in Stevens-Johnson's syndrome / toxic epidermal necrolysis, but the results seem promising.
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spelling Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three casesdrug toxicityepidermal necrolysis, toxicfas ligand proteinimmunoglobulins, intravenousStevens-Johnson's syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatoses, that lead to keratinocyte apoptosis induced by interactions between Fas (cell death receptor) and soluble Fas-ligand, present in serum of Stevens-Johnson's syndrome / toxic epidermal necrolysis patients. Anti-Fas antibodies in intravenous immunoglobulin (IVIG) would block the apoptosis cascade. Three cases of toxic epidermal necrolysis occurred in one male and two female patients, after use of allopurinol, leprosy multidrug therapy concomitant with dipyrone, and diclofenac. The cases were treated with intravenous immunoglobulin 2-3 mg/kg and prednisone 20-50 mg/day. The interruption of new lesions outbreak and reepithelization were extremely fast after the use of intravenous immunoglobulin, without adverse effects. Controlled studies are needed to confirm the efficacy of intravenous immunoglobulin in Stevens-Johnson's syndrome / toxic epidermal necrolysis, but the results seem promising.Sociedade Brasileira de Dermatologia2012-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000300022Anais Brasileiros de Dermatologia v.87 n.3 2012reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962012000300022info:eu-repo/semantics/openAccessComparin,CristianeHans Filho,GünterTakita,Luiz CarlosCosta,Nayara de Castro WiziackNascimento,Roberta Ayres Ferreira doNanni,Lidiane de Oliveira Costaeng2012-06-15T00:00:00Zoai:scielo:S0365-05962012000300022Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2012-06-15T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
title Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
spellingShingle Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
Comparin,Cristiane
drug toxicity
epidermal necrolysis, toxic
fas ligand protein
immunoglobulins, intravenous
title_short Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
title_full Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
title_fullStr Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
title_full_unstemmed Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
title_sort Treatment of toxic epidermal necrolysis with intravenous immunoglobulin: a series of three cases
author Comparin,Cristiane
author_facet Comparin,Cristiane
Hans Filho,Günter
Takita,Luiz Carlos
Costa,Nayara de Castro Wiziack
Nascimento,Roberta Ayres Ferreira do
Nanni,Lidiane de Oliveira Costa
author_role author
author2 Hans Filho,Günter
Takita,Luiz Carlos
Costa,Nayara de Castro Wiziack
Nascimento,Roberta Ayres Ferreira do
Nanni,Lidiane de Oliveira Costa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Comparin,Cristiane
Hans Filho,Günter
Takita,Luiz Carlos
Costa,Nayara de Castro Wiziack
Nascimento,Roberta Ayres Ferreira do
Nanni,Lidiane de Oliveira Costa
dc.subject.por.fl_str_mv drug toxicity
epidermal necrolysis, toxic
fas ligand protein
immunoglobulins, intravenous
topic drug toxicity
epidermal necrolysis, toxic
fas ligand protein
immunoglobulins, intravenous
description Stevens-Johnson's syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatoses, that lead to keratinocyte apoptosis induced by interactions between Fas (cell death receptor) and soluble Fas-ligand, present in serum of Stevens-Johnson's syndrome / toxic epidermal necrolysis patients. Anti-Fas antibodies in intravenous immunoglobulin (IVIG) would block the apoptosis cascade. Three cases of toxic epidermal necrolysis occurred in one male and two female patients, after use of allopurinol, leprosy multidrug therapy concomitant with dipyrone, and diclofenac. The cases were treated with intravenous immunoglobulin 2-3 mg/kg and prednisone 20-50 mg/day. The interruption of new lesions outbreak and reepithelization were extremely fast after the use of intravenous immunoglobulin, without adverse effects. Controlled studies are needed to confirm the efficacy of intravenous immunoglobulin in Stevens-Johnson's syndrome / toxic epidermal necrolysis, but the results seem promising.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000300022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000300022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0365-05962012000300022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.87 n.3 2012
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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