The use of ustekinumab in a patient with severe psoriasis and positive HBV serology

Detalhes bibliográficos
Autor(a) principal: Steglich,Raquel Bissacotti
Data de Publicação: 2014
Outros Autores: Meneghello,Luana Pizarro, Carvalho,André Vicente Esteves de, Cheinquer,Hugo, Muller,Fernanda Melo, Reginatto,Flávia Pereira
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000400652
Resumo: Psoriasis is a chronic inflammatory, immune-mediated disease that affects 1% to 2% of the world's population. Immunobiological medications are prescribed for certain patients with severe forms of psoriasis, however, these drugs increase the risk of reactivation of viral diseases such as hepatitis B. We report the case of a patient with severe psoriasis with positive serology for the Hepatitis B virus, who received ustekinumab (a human monoclonal antibody against interleukin 12 and 23). In this patient, the use of ustekinumab did not reactivate the Hepatitis B virus. Given the high prevalence of chronic viral infections in patients who are candidates for biologic therapy, as well as the potential for reactivate chronic viral illness, randomized controlled studies are needed to assess the risks and benefits of such therapy in these populations.
id SBD-1_200eddf66fc33023da1674dcfdb3a6c4
oai_identifier_str oai:scielo:S0365-05962014000400652
network_acronym_str SBD-1
network_name_str Anais brasileiros de dermatologia (Online)
repository_id_str
spelling The use of ustekinumab in a patient with severe psoriasis and positive HBV serologyHepatitis BHepatitis B virusPsoriasisPsoriasis is a chronic inflammatory, immune-mediated disease that affects 1% to 2% of the world's population. Immunobiological medications are prescribed for certain patients with severe forms of psoriasis, however, these drugs increase the risk of reactivation of viral diseases such as hepatitis B. We report the case of a patient with severe psoriasis with positive serology for the Hepatitis B virus, who received ustekinumab (a human monoclonal antibody against interleukin 12 and 23). In this patient, the use of ustekinumab did not reactivate the Hepatitis B virus. Given the high prevalence of chronic viral infections in patients who are candidates for biologic therapy, as well as the potential for reactivate chronic viral illness, randomized controlled studies are needed to assess the risks and benefits of such therapy in these populations.Sociedade Brasileira de Dermatologia2014-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000400652Anais Brasileiros de Dermatologia v.89 n.4 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20143013info:eu-repo/semantics/openAccessSteglich,Raquel BissacottiMeneghello,Luana PizarroCarvalho,André Vicente Esteves deCheinquer,HugoMuller,Fernanda MeloReginatto,Flávia Pereiraeng2014-07-23T00:00:00Zoai:scielo:S0365-05962014000400652Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2014-07-23T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
title The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
spellingShingle The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
Steglich,Raquel Bissacotti
Hepatitis B
Hepatitis B virus
Psoriasis
title_short The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
title_full The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
title_fullStr The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
title_full_unstemmed The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
title_sort The use of ustekinumab in a patient with severe psoriasis and positive HBV serology
author Steglich,Raquel Bissacotti
author_facet Steglich,Raquel Bissacotti
Meneghello,Luana Pizarro
Carvalho,André Vicente Esteves de
Cheinquer,Hugo
Muller,Fernanda Melo
Reginatto,Flávia Pereira
author_role author
author2 Meneghello,Luana Pizarro
Carvalho,André Vicente Esteves de
Cheinquer,Hugo
Muller,Fernanda Melo
Reginatto,Flávia Pereira
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Steglich,Raquel Bissacotti
Meneghello,Luana Pizarro
Carvalho,André Vicente Esteves de
Cheinquer,Hugo
Muller,Fernanda Melo
Reginatto,Flávia Pereira
dc.subject.por.fl_str_mv Hepatitis B
Hepatitis B virus
Psoriasis
topic Hepatitis B
Hepatitis B virus
Psoriasis
description Psoriasis is a chronic inflammatory, immune-mediated disease that affects 1% to 2% of the world's population. Immunobiological medications are prescribed for certain patients with severe forms of psoriasis, however, these drugs increase the risk of reactivation of viral diseases such as hepatitis B. We report the case of a patient with severe psoriasis with positive serology for the Hepatitis B virus, who received ustekinumab (a human monoclonal antibody against interleukin 12 and 23). In this patient, the use of ustekinumab did not reactivate the Hepatitis B virus. Given the high prevalence of chronic viral infections in patients who are candidates for biologic therapy, as well as the potential for reactivate chronic viral illness, randomized controlled studies are needed to assess the risks and benefits of such therapy in these populations.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000400652
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000400652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20143013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.89 n.4 2014
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
_version_ 1752126419835551744

Registros relacionados