Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500611 |
Resumo: | Abstract: Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). Objective: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. Methods: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. Results: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). Conclusion: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population. |
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Anais brasileiros de dermatologia (Online) |
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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern TurkeyMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, single nucleotidePsoriasisTurkeyAbstract: Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). Objective: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. Methods: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. Results: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). Conclusion: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.Sociedade Brasileira de Dermatologia2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500611Anais Brasileiros de Dermatologia v.91 n.5 2016reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20164766info:eu-repo/semantics/openAccessIzmirli,MuzeyyenSen,Bilge BulbulRifaioglu,EminenurGogebakan,BulentAldemir,OzgurSen,TubaEkiz,OzlemAlptekin,Davuteng2016-11-04T00:00:00Zoai:scielo:S0365-05962016000500611Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2016-11-04T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
title |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
spellingShingle |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey Izmirli,Muzeyyen Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism, single nucleotide Psoriasis Turkey |
title_short |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
title_full |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
title_fullStr |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
title_full_unstemmed |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
title_sort |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey |
author |
Izmirli,Muzeyyen |
author_facet |
Izmirli,Muzeyyen Sen,Bilge Bulbul Rifaioglu,Eminenur Gogebakan,Bulent Aldemir,Ozgur Sen,Tuba Ekiz,Ozlem Alptekin,Davut |
author_role |
author |
author2 |
Sen,Bilge Bulbul Rifaioglu,Eminenur Gogebakan,Bulent Aldemir,Ozgur Sen,Tuba Ekiz,Ozlem Alptekin,Davut |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Izmirli,Muzeyyen Sen,Bilge Bulbul Rifaioglu,Eminenur Gogebakan,Bulent Aldemir,Ozgur Sen,Tuba Ekiz,Ozlem Alptekin,Davut |
dc.subject.por.fl_str_mv |
Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism, single nucleotide Psoriasis Turkey |
topic |
Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism, single nucleotide Psoriasis Turkey |
description |
Abstract: Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). Objective: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. Methods: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. Results: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). Conclusion: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500611 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500611 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20164766 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.91 n.5 2016 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126421372764160 |