BRAFV600E and KIT immunoexpression in early-stage melanoma

Detalhes bibliográficos
Autor(a) principal: Germano,Andressa
Data de Publicação: 2019
Outros Autores: Cardili,Leonardo, Carapeto,Fernando Cintra Lopes, Landman,Gilles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000400458
Resumo: Abstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
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spelling BRAFV600E and KIT immunoexpression in early-stage melanomaBiomarkers, pharmacologicalEarly diagnosisMelanomaAbstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.Sociedade Brasileira de Dermatologia2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000400458Anais Brasileiros de Dermatologia v.94 n.4 2019reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20198349info:eu-repo/semantics/openAccessGermano,AndressaCardili,LeonardoCarapeto,Fernando Cintra LopesLandman,Gilleseng2019-10-11T00:00:00Zoai:scielo:S0365-05962019000400458Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2019-10-11T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv BRAFV600E and KIT immunoexpression in early-stage melanoma
title BRAFV600E and KIT immunoexpression in early-stage melanoma
spellingShingle BRAFV600E and KIT immunoexpression in early-stage melanoma
Germano,Andressa
Biomarkers, pharmacological
Early diagnosis
Melanoma
title_short BRAFV600E and KIT immunoexpression in early-stage melanoma
title_full BRAFV600E and KIT immunoexpression in early-stage melanoma
title_fullStr BRAFV600E and KIT immunoexpression in early-stage melanoma
title_full_unstemmed BRAFV600E and KIT immunoexpression in early-stage melanoma
title_sort BRAFV600E and KIT immunoexpression in early-stage melanoma
author Germano,Andressa
author_facet Germano,Andressa
Cardili,Leonardo
Carapeto,Fernando Cintra Lopes
Landman,Gilles
author_role author
author2 Cardili,Leonardo
Carapeto,Fernando Cintra Lopes
Landman,Gilles
author2_role author
author
author
dc.contributor.author.fl_str_mv Germano,Andressa
Cardili,Leonardo
Carapeto,Fernando Cintra Lopes
Landman,Gilles
dc.subject.por.fl_str_mv Biomarkers, pharmacological
Early diagnosis
Melanoma
topic Biomarkers, pharmacological
Early diagnosis
Melanoma
description Abstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000400458
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962019000400458
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20198349
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.94 n.4 2019
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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