Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,

Detalhes bibliográficos
Autor(a) principal: Sampaio,Raimunda Nonata Ribeiro
Data de Publicação: 2021
Outros Autores: Ferreira,Marina Freitas, Martins,Sofia Sales, Motta,Jorgeth de Oliveira Carneiro da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602
Resumo: Abstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.
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spelling Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,AllopurinolAntimonyRecurrenceTherapyDiffuse cutaneous leishmaniasisAbstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.Sociedade Brasileira de Dermatologia2021-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602Anais Brasileiros de Dermatologia v.96 n.5 2021reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2021.03.003info:eu-repo/semantics/openAccessSampaio,Raimunda Nonata RibeiroFerreira,Marina FreitasMartins,Sofia SalesMotta,Jorgeth de Oliveira Carneiro daeng2021-10-14T00:00:00Zoai:scielo:S0365-05962021000500602Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2021-10-14T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
spellingShingle Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
Sampaio,Raimunda Nonata Ribeiro
Allopurinol
Antimony
Recurrence
Therapy
Diffuse cutaneous leishmaniasis
title_short Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_full Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_fullStr Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_full_unstemmed Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
title_sort Successful treatment of diffuse cutaneous leishmaniasis caused by Leishmania amazonensis,
author Sampaio,Raimunda Nonata Ribeiro
author_facet Sampaio,Raimunda Nonata Ribeiro
Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
author_role author
author2 Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
author2_role author
author
author
dc.contributor.author.fl_str_mv Sampaio,Raimunda Nonata Ribeiro
Ferreira,Marina Freitas
Martins,Sofia Sales
Motta,Jorgeth de Oliveira Carneiro da
dc.subject.por.fl_str_mv Allopurinol
Antimony
Recurrence
Therapy
Diffuse cutaneous leishmaniasis
topic Allopurinol
Antimony
Recurrence
Therapy
Diffuse cutaneous leishmaniasis
description Abstract Diffuse cutaneous leishmaniasis is a rare universal disease associated with an inadequate host cell immune response, caused by different species: infantum, aethiopica, major, mexicana, and others, which presents the challenge of a poor therapeutic response. In Brazil, it is caused by L. amazonensis. A case confirmed by histopathology with an abundance of vacuolated macrophages full of amastigotes and lymphocyte scarcity, identified by RFLP-ITS1PCR and in vitro decrease and exhaustion of the host cell immune response to L. amazonensis antigen, was treated early (3 months after the onset) with Glucantime (2 months) and allopurinol (29 months) with clinical cure, after a follow-up for 30 months after treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962021000500602
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.abd.2021.03.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.96 n.5 2021
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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