Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,

Detalhes bibliográficos
Autor(a) principal: Bagatin,Ediléia
Data de Publicação: 2020
Outros Autores: Costa,Caroline Sousa, Rocha,Marco Alexandre Dias da, Picosse,Fabíola Rosa, Kamamoto,Cristhine Souza Leão, Pirmez,Rodrigo, Ianhez,Mayra, Miot,Hélio Amante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000700019
Resumo: Abstract Background: Isotretinoin is a synthetic retinoid, derived from vitamin A, with multiple mechanisms of action and highly effective in the treatment of acne, despite common adverse events, manageable and dose-dependent. Dose-independent teratogenicity is the most serious. Therefore, off-label prescriptions require strict criteria. Objective: To communicate the experience and recommendation of Brazilian dermatologists on oral use of the drug in dermatology. Methods: Eight experts from five universities were appointed by the Brazilian Society of Dermatology to develop a consensus on indications for this drug. Through the adapted DELPHI methodology, relevant elements were listed and an extensive analysis of the literature was carried out. The consensus was defined with the approval of at least 70% of the experts. Results: With 100% approval from the authors, there was no doubt about the efficacy of oral isotretinoin in the treatment of acne, including as an adjunct in the correction of scars. Common and manageable common adverse events are mucocutaneous in nature. Others, such as growth retardation, abnormal healing, depression, and inflammatory bowel disease have been thoroughly investigated, and there is no evidence of a causal association; they are rare, individual, and should not contraindicate the use of the drug. Regarding unapproved indications, it may represent an option in cases of refractory rosacea, severe seborrheic dermatitis, stabilization of field cancerization with advanced photoaging and, although incipient, frontal fibrosing alopecia. For keratinization disorders, acitretin performs better. In the opinion of the authors, indications for purely esthetic purposes or oil control are not recommended, particularly for women of childbearing age. Conclusions: Approved and non-approved indications, efficacy and adverse effects of oral isotretinoin in dermatology were presented and critically evaluated.
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spelling Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,Acne vulgarisDermatitis, seborrheicIsotretinoinRosaceaVitamin AAbstract Background: Isotretinoin is a synthetic retinoid, derived from vitamin A, with multiple mechanisms of action and highly effective in the treatment of acne, despite common adverse events, manageable and dose-dependent. Dose-independent teratogenicity is the most serious. Therefore, off-label prescriptions require strict criteria. Objective: To communicate the experience and recommendation of Brazilian dermatologists on oral use of the drug in dermatology. Methods: Eight experts from five universities were appointed by the Brazilian Society of Dermatology to develop a consensus on indications for this drug. Through the adapted DELPHI methodology, relevant elements were listed and an extensive analysis of the literature was carried out. The consensus was defined with the approval of at least 70% of the experts. Results: With 100% approval from the authors, there was no doubt about the efficacy of oral isotretinoin in the treatment of acne, including as an adjunct in the correction of scars. Common and manageable common adverse events are mucocutaneous in nature. Others, such as growth retardation, abnormal healing, depression, and inflammatory bowel disease have been thoroughly investigated, and there is no evidence of a causal association; they are rare, individual, and should not contraindicate the use of the drug. Regarding unapproved indications, it may represent an option in cases of refractory rosacea, severe seborrheic dermatitis, stabilization of field cancerization with advanced photoaging and, although incipient, frontal fibrosing alopecia. For keratinization disorders, acitretin performs better. In the opinion of the authors, indications for purely esthetic purposes or oil control are not recommended, particularly for women of childbearing age. Conclusions: Approved and non-approved indications, efficacy and adverse effects of oral isotretinoin in dermatology were presented and critically evaluated.Sociedade Brasileira de Dermatologia2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000700019Anais Brasileiros de Dermatologia v.95 suppl.1 2020reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2020.09.001info:eu-repo/semantics/openAccessBagatin,EdiléiaCosta,Caroline SousaRocha,Marco Alexandre Dias daPicosse,Fabíola RosaKamamoto,Cristhine Souza LeãoPirmez,RodrigoIanhez,MayraMiot,Hélio Amanteeng2021-03-22T00:00:00Zoai:scielo:S0365-05962020000700019Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2021-03-22T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
title Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
spellingShingle Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
Bagatin,Ediléia
Acne vulgaris
Dermatitis, seborrheic
Isotretinoin
Rosacea
Vitamin A
title_short Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
title_full Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
title_fullStr Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
title_full_unstemmed Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
title_sort Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology,
author Bagatin,Ediléia
author_facet Bagatin,Ediléia
Costa,Caroline Sousa
Rocha,Marco Alexandre Dias da
Picosse,Fabíola Rosa
Kamamoto,Cristhine Souza Leão
Pirmez,Rodrigo
Ianhez,Mayra
Miot,Hélio Amante
author_role author
author2 Costa,Caroline Sousa
Rocha,Marco Alexandre Dias da
Picosse,Fabíola Rosa
Kamamoto,Cristhine Souza Leão
Pirmez,Rodrigo
Ianhez,Mayra
Miot,Hélio Amante
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bagatin,Ediléia
Costa,Caroline Sousa
Rocha,Marco Alexandre Dias da
Picosse,Fabíola Rosa
Kamamoto,Cristhine Souza Leão
Pirmez,Rodrigo
Ianhez,Mayra
Miot,Hélio Amante
dc.subject.por.fl_str_mv Acne vulgaris
Dermatitis, seborrheic
Isotretinoin
Rosacea
Vitamin A
topic Acne vulgaris
Dermatitis, seborrheic
Isotretinoin
Rosacea
Vitamin A
description Abstract Background: Isotretinoin is a synthetic retinoid, derived from vitamin A, with multiple mechanisms of action and highly effective in the treatment of acne, despite common adverse events, manageable and dose-dependent. Dose-independent teratogenicity is the most serious. Therefore, off-label prescriptions require strict criteria. Objective: To communicate the experience and recommendation of Brazilian dermatologists on oral use of the drug in dermatology. Methods: Eight experts from five universities were appointed by the Brazilian Society of Dermatology to develop a consensus on indications for this drug. Through the adapted DELPHI methodology, relevant elements were listed and an extensive analysis of the literature was carried out. The consensus was defined with the approval of at least 70% of the experts. Results: With 100% approval from the authors, there was no doubt about the efficacy of oral isotretinoin in the treatment of acne, including as an adjunct in the correction of scars. Common and manageable common adverse events are mucocutaneous in nature. Others, such as growth retardation, abnormal healing, depression, and inflammatory bowel disease have been thoroughly investigated, and there is no evidence of a causal association; they are rare, individual, and should not contraindicate the use of the drug. Regarding unapproved indications, it may represent an option in cases of refractory rosacea, severe seborrheic dermatitis, stabilization of field cancerization with advanced photoaging and, although incipient, frontal fibrosing alopecia. For keratinization disorders, acitretin performs better. In the opinion of the authors, indications for purely esthetic purposes or oil control are not recommended, particularly for women of childbearing age. Conclusions: Approved and non-approved indications, efficacy and adverse effects of oral isotretinoin in dermatology were presented and critically evaluated.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000700019
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1016/j.abd.2020.09.001
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.95 suppl.1 2020
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
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