OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005 |
Resumo: | BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels. |
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OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesisCytokinesImmunohistochemistryLeishmaniasisLeishmaniasis cutaneousBACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.Sociedade Brasileira de Dermatologia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005Anais Brasileiros de Dermatologia v.87 n.6 2012reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962012000600005info:eu-repo/semantics/openAccessDomingos,Patrícia Luciana BatistaViana,Agostinho GonçalvesFraga,Carlos Alberto de CarvalhoBonan,Paulo Rogério Ferretieng2012-11-27T00:00:00Zoai:scielo:S0365-05962012000600005Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2012-11-27T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
title |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
spellingShingle |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis Domingos,Patrícia Luciana Batista Cytokines Immunohistochemistry Leishmaniasis Leishmaniasis cutaneous |
title_short |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
title_full |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
title_fullStr |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
title_full_unstemmed |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
title_sort |
OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis |
author |
Domingos,Patrícia Luciana Batista |
author_facet |
Domingos,Patrícia Luciana Batista Viana,Agostinho Gonçalves Fraga,Carlos Alberto de Carvalho Bonan,Paulo Rogério Ferreti |
author_role |
author |
author2 |
Viana,Agostinho Gonçalves Fraga,Carlos Alberto de Carvalho Bonan,Paulo Rogério Ferreti |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Domingos,Patrícia Luciana Batista Viana,Agostinho Gonçalves Fraga,Carlos Alberto de Carvalho Bonan,Paulo Rogério Ferreti |
dc.subject.por.fl_str_mv |
Cytokines Immunohistochemistry Leishmaniasis Leishmaniasis cutaneous |
topic |
Cytokines Immunohistochemistry Leishmaniasis Leishmaniasis cutaneous |
description |
BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0365-05962012000600005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.87 n.6 2012 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126418322456576 |