OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis

Detalhes bibliográficos
Autor(a) principal: Domingos,Patrícia Luciana Batista
Data de Publicação: 2012
Outros Autores: Viana,Agostinho Gonçalves, Fraga,Carlos Alberto de Carvalho, Bonan,Paulo Rogério Ferreti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005
Resumo: BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.
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spelling OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesisCytokinesImmunohistochemistryLeishmaniasisLeishmaniasis cutaneousBACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.Sociedade Brasileira de Dermatologia2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005Anais Brasileiros de Dermatologia v.87 n.6 2012reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962012000600005info:eu-repo/semantics/openAccessDomingos,Patrícia Luciana BatistaViana,Agostinho GonçalvesFraga,Carlos Alberto de CarvalhoBonan,Paulo Rogério Ferretieng2012-11-27T00:00:00Zoai:scielo:S0365-05962012000600005Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2012-11-27T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
title OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
spellingShingle OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
Domingos,Patrícia Luciana Batista
Cytokines
Immunohistochemistry
Leishmaniasis
Leishmaniasis cutaneous
title_short OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
title_full OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
title_fullStr OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
title_full_unstemmed OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
title_sort OX40+ T lymphocytes and IFN-γ are associated with American tegumentary leishmaniasis pathogenesis
author Domingos,Patrícia Luciana Batista
author_facet Domingos,Patrícia Luciana Batista
Viana,Agostinho Gonçalves
Fraga,Carlos Alberto de Carvalho
Bonan,Paulo Rogério Ferreti
author_role author
author2 Viana,Agostinho Gonçalves
Fraga,Carlos Alberto de Carvalho
Bonan,Paulo Rogério Ferreti
author2_role author
author
author
dc.contributor.author.fl_str_mv Domingos,Patrícia Luciana Batista
Viana,Agostinho Gonçalves
Fraga,Carlos Alberto de Carvalho
Bonan,Paulo Rogério Ferreti
dc.subject.por.fl_str_mv Cytokines
Immunohistochemistry
Leishmaniasis
Leishmaniasis cutaneous
topic Cytokines
Immunohistochemistry
Leishmaniasis
Leishmaniasis cutaneous
description BACKGROUND: Leishmaniases are zoonoses considered a public health problem, representing a complex group of diseases with a broad clinical spectrum and epidemiological diversity. Leishmaniasis is caused by several species of protozoa of the genus Leishmania. The evolution of the pathology and the resolution of the leishmaniasis are dependent mainly on the Leishmania species involved, although the cytokine profile plays an important role in the development of the immune response. OBJECTIVES: The purpose of our study was to evaluate the immune response of patients affected by lesions of cutaneous leishmaniasis by immunostaining of the OX40, CD20, IFN-γ and IL-4 proteins. METHODS: The tissue samples were collected from indolent skin ulcers confirmed as cutaneous leishmaniasis of 41 patients aged between six and 90 years. The lesions were submitted to OX40, CD20, INF-γ and IL-4 immunolabeling. RESULTS: We observed a statistically significant higher expression of IFN-γ compared with IL-4 (p=0.009). Besides, OX40 had higher expression when compared with CD20 (p<0.001). CONCLUSION: The present study indicates that the immune response in lesions of cutaneous leishmaniasis is associated with a healing process, which can be explained by the higher expression of IFN-γ when compared with IL4 protein levels.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000600005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0365-05962012000600005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.87 n.6 2012
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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