Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi

Detalhes bibliográficos
Autor(a) principal: Sartori,Debora Sarzi
Data de Publicação: 2022
Outros Autores: Almeida,Antônia Larangeira de, Oliveira,Gabriel Santana Pereira de, Almeida Jr,Hiram Larangeira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200240
Resumo: Abstract Panitumumab is a monoclonal antibody against the epidermal growth factor receptor used in metastatic colorectal cancer; in addition to tumor cells, it acts on epidermal keratinocytes and on the outer root sheath and presents skin toxicity in up to 90% of cases. A scanning electron microscope was used to examine the eyelashes and hairs of a 65-year-old patient with eyelash trichomegaly, curly hair, and paronychia undergoing treatment with panitumumab. Grooving in the hair shafts were identified, which were more evident in the eyelashes. Similar to oral epidermal growth factor inhibitors (erlotinib and gefitinib), panitumumab can cause acquired pili canaliculi.
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spelling Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculiMicroscopy, electronPanitumumabScalp dermatosesAbstract Panitumumab is a monoclonal antibody against the epidermal growth factor receptor used in metastatic colorectal cancer; in addition to tumor cells, it acts on epidermal keratinocytes and on the outer root sheath and presents skin toxicity in up to 90% of cases. A scanning electron microscope was used to examine the eyelashes and hairs of a 65-year-old patient with eyelash trichomegaly, curly hair, and paronychia undergoing treatment with panitumumab. Grooving in the hair shafts were identified, which were more evident in the eyelashes. Similar to oral epidermal growth factor inhibitors (erlotinib and gefitinib), panitumumab can cause acquired pili canaliculi.Sociedade Brasileira de Dermatologia2022-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200240Anais Brasileiros de Dermatologia v.97 n.2 2022reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2021.03.011info:eu-repo/semantics/openAccessSartori,Debora SarziAlmeida,Antônia Larangeira deOliveira,Gabriel Santana Pereira deAlmeida Jr,Hiram Larangeira deeng2022-04-18T00:00:00Zoai:scielo:S0365-05962022000200240Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2022-04-18T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
title Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
spellingShingle Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
Sartori,Debora Sarzi
Microscopy, electron
Panitumumab
Scalp dermatoses
title_short Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
title_full Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
title_fullStr Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
title_full_unstemmed Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
title_sort Scanning electron microscopy of panitumumab-induced eyelash and hair alterations - Pili canaliculi
author Sartori,Debora Sarzi
author_facet Sartori,Debora Sarzi
Almeida,Antônia Larangeira de
Oliveira,Gabriel Santana Pereira de
Almeida Jr,Hiram Larangeira de
author_role author
author2 Almeida,Antônia Larangeira de
Oliveira,Gabriel Santana Pereira de
Almeida Jr,Hiram Larangeira de
author2_role author
author
author
dc.contributor.author.fl_str_mv Sartori,Debora Sarzi
Almeida,Antônia Larangeira de
Oliveira,Gabriel Santana Pereira de
Almeida Jr,Hiram Larangeira de
dc.subject.por.fl_str_mv Microscopy, electron
Panitumumab
Scalp dermatoses
topic Microscopy, electron
Panitumumab
Scalp dermatoses
description Abstract Panitumumab is a monoclonal antibody against the epidermal growth factor receptor used in metastatic colorectal cancer; in addition to tumor cells, it acts on epidermal keratinocytes and on the outer root sheath and presents skin toxicity in up to 90% of cases. A scanning electron microscope was used to examine the eyelashes and hairs of a 65-year-old patient with eyelash trichomegaly, curly hair, and paronychia undergoing treatment with panitumumab. Grooving in the hair shafts were identified, which were more evident in the eyelashes. Similar to oral epidermal growth factor inhibitors (erlotinib and gefitinib), panitumumab can cause acquired pili canaliculi.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200240
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200240
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.abd.2021.03.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.97 n.2 2022
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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