Dissecting the pathways of tumour escape: " question of life and death?"

Detalhes bibliográficos
Autor(a) principal: Tchernev,Georgi
Data de Publicação: 2010
Outros Autores: Nenoff,Pietro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000200022
Resumo: Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction pathways within the tumour cells and between these and the immune system. The article focuses attention on the evolution of the melanocytic naevi in the direction of a dysplastic or tumour cell. The determination of single molecules as prognostic parameters within cancer genesis seems to be problematic. New hopes are being placed on the treatment with TW-37, ABT-737 and TAT-Bim, which, to an extent, are able to support the programmed cell death. The clinical importance of these innovative therapies remains to be seen and should therefore, be viewed with considerable criticism.
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spelling Dissecting the pathways of tumour escape: " question of life and death?"Apoptosisbcl-2-Associated X ProteinCell cycleHLA antigensApoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction pathways within the tumour cells and between these and the immune system. The article focuses attention on the evolution of the melanocytic naevi in the direction of a dysplastic or tumour cell. The determination of single molecules as prognostic parameters within cancer genesis seems to be problematic. New hopes are being placed on the treatment with TW-37, ABT-737 and TAT-Bim, which, to an extent, are able to support the programmed cell death. The clinical importance of these innovative therapies remains to be seen and should therefore, be viewed with considerable criticism.Sociedade Brasileira de Dermatologia2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000200022Anais Brasileiros de Dermatologia v.85 n.2 2010reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/S0365-05962010000200022info:eu-repo/semantics/openAccessTchernev,GeorgiNenoff,Pietroeng2010-06-23T00:00:00Zoai:scielo:S0365-05962010000200022Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2010-06-23T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Dissecting the pathways of tumour escape: " question of life and death?"
title Dissecting the pathways of tumour escape: " question of life and death?"
spellingShingle Dissecting the pathways of tumour escape: " question of life and death?"
Tchernev,Georgi
Apoptosis
bcl-2-Associated X Protein
Cell cycle
HLA antigens
title_short Dissecting the pathways of tumour escape: " question of life and death?"
title_full Dissecting the pathways of tumour escape: " question of life and death?"
title_fullStr Dissecting the pathways of tumour escape: " question of life and death?"
title_full_unstemmed Dissecting the pathways of tumour escape: " question of life and death?"
title_sort Dissecting the pathways of tumour escape: " question of life and death?"
author Tchernev,Georgi
author_facet Tchernev,Georgi
Nenoff,Pietro
author_role author
author2 Nenoff,Pietro
author2_role author
dc.contributor.author.fl_str_mv Tchernev,Georgi
Nenoff,Pietro
dc.subject.por.fl_str_mv Apoptosis
bcl-2-Associated X Protein
Cell cycle
HLA antigens
topic Apoptosis
bcl-2-Associated X Protein
Cell cycle
HLA antigens
description Apoptotic pathways are providing important saveguard mechanisms in protection from cancer by eliminating altered and often harmful cells. The disturbances of cell proliferation, differentiation and apoptosis are also found on specific signal-transduction pathways within the tumour cells and between these and the immune system. The article focuses attention on the evolution of the melanocytic naevi in the direction of a dysplastic or tumour cell. The determination of single molecules as prognostic parameters within cancer genesis seems to be problematic. New hopes are being placed on the treatment with TW-37, ABT-737 and TAT-Bim, which, to an extent, are able to support the programmed cell death. The clinical importance of these innovative therapies remains to be seen and should therefore, be viewed with considerable criticism.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000200022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962010000200022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0365-05962010000200022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.85 n.2 2010
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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