Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500807 |
Resumo: | Histiocytic sarcoma is a rare hematologic malignant neoplasia originating from histiocytic or dendritic cell clones. The lesions may be in nodal or extranodal sites, most commonly in the gastrointestinal tract. A small number of cases presents as unique cutaneous lesions. The definitive diagnosis is made by positivity for the immunohistochemical markers CD163, CD68, CD4 and lysozyme. The treatment is controversial, often with combined systemic chemotherapy. This is a case of cutaneous histiocytic sarcoma in an 82-year-old patient presenting two nodular lesions in the breast and right arm which were treated with simple excision and multidisciplinary follow-up, avoiding aggressive management and exhaustive investigations. Although most studies report aggressive evolution, the patient had good and stable clinical status during the twelve-month follow-up period. |
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Anais brasileiros de dermatologia (Online) |
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Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmasHistiocytic disorders, malignantHistiocytic sarcomaImmunohistochemistrySarcomaTherapeuticsTreatment outcomeHistiocytic sarcoma is a rare hematologic malignant neoplasia originating from histiocytic or dendritic cell clones. The lesions may be in nodal or extranodal sites, most commonly in the gastrointestinal tract. A small number of cases presents as unique cutaneous lesions. The definitive diagnosis is made by positivity for the immunohistochemical markers CD163, CD68, CD4 and lysozyme. The treatment is controversial, often with combined systemic chemotherapy. This is a case of cutaneous histiocytic sarcoma in an 82-year-old patient presenting two nodular lesions in the breast and right arm which were treated with simple excision and multidisciplinary follow-up, avoiding aggressive management and exhaustive investigations. Although most studies report aggressive evolution, the patient had good and stable clinical status during the twelve-month follow-up period.Sociedade Brasileira de Dermatologia2013-10-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500807Anais Brasileiros de Dermatologia v.88 n.5 2013reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20132070info:eu-repo/semantics/openAccessTrevisan,FlaviaXavier,Celia AntoniaPinto,Clovis Antonio LopesCattete,Fernanda GomesStock,Fabiola SchaufflerMartins,Marcella Ledoeng2013-10-28T00:00:00Zoai:scielo:S0365-05962013000500807Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2013-10-28T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
title |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
spellingShingle |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas Trevisan,Flavia Histiocytic disorders, malignant Histiocytic sarcoma Immunohistochemistry Sarcoma Therapeutics Treatment outcome |
title_short |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
title_full |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
title_fullStr |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
title_full_unstemmed |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
title_sort |
Case report of cutaneous histiocytic sarcoma: diagnostic and therapeutic dilemmas |
author |
Trevisan,Flavia |
author_facet |
Trevisan,Flavia Xavier,Celia Antonia Pinto,Clovis Antonio Lopes Cattete,Fernanda Gomes Stock,Fabiola Schauffler Martins,Marcella Ledo |
author_role |
author |
author2 |
Xavier,Celia Antonia Pinto,Clovis Antonio Lopes Cattete,Fernanda Gomes Stock,Fabiola Schauffler Martins,Marcella Ledo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Trevisan,Flavia Xavier,Celia Antonia Pinto,Clovis Antonio Lopes Cattete,Fernanda Gomes Stock,Fabiola Schauffler Martins,Marcella Ledo |
dc.subject.por.fl_str_mv |
Histiocytic disorders, malignant Histiocytic sarcoma Immunohistochemistry Sarcoma Therapeutics Treatment outcome |
topic |
Histiocytic disorders, malignant Histiocytic sarcoma Immunohistochemistry Sarcoma Therapeutics Treatment outcome |
description |
Histiocytic sarcoma is a rare hematologic malignant neoplasia originating from histiocytic or dendritic cell clones. The lesions may be in nodal or extranodal sites, most commonly in the gastrointestinal tract. A small number of cases presents as unique cutaneous lesions. The definitive diagnosis is made by positivity for the immunohistochemical markers CD163, CD68, CD4 and lysozyme. The treatment is controversial, often with combined systemic chemotherapy. This is a case of cutaneous histiocytic sarcoma in an 82-year-old patient presenting two nodular lesions in the breast and right arm which were treated with simple excision and multidisciplinary follow-up, avoiding aggressive management and exhaustive investigations. Although most studies report aggressive evolution, the patient had good and stable clinical status during the twelve-month follow-up period. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500807 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500807 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20132070 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.88 n.5 2013 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126419045974016 |