Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200223 |
Resumo: | Abstract In immunosuppressed patients, dermatophytosis can be more invasive, affecting the dermis and subcutaneous tissues. The authors describe the cases of two patients with kidney and heart transplanted, respectively, that developed a deep dermatophytosis caused by Trichophyton rubrum, confirmed by culture and DNA sequencing. Both patients had concomitant onychomycosis, and both were treated with itraconazole for about two months, which was interrupted due to pharmacological interactions with the immunosuppressive drugs and switched to terbinafine, leading to clinical resolution within four months. Deep dermatophytosis should be considered when dealing with immunocompromised patients, especially when a superficial dermatophytosis is present. Oral treatment is necessary and terbinafine is a preferable option in solid organ transplant recipients because it has less pharmacological interactions. |
id |
SBD-1_b0131b6a3c8449d18528eab735281ebb |
---|---|
oai_identifier_str |
oai:scielo:S0365-05962022000200223 |
network_acronym_str |
SBD-1 |
network_name_str |
Anais brasileiros de dermatologia (Online) |
repository_id_str |
|
spelling |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patientsDermatofitoseImmunosuppressionTransplantTrichophytonAbstract In immunosuppressed patients, dermatophytosis can be more invasive, affecting the dermis and subcutaneous tissues. The authors describe the cases of two patients with kidney and heart transplanted, respectively, that developed a deep dermatophytosis caused by Trichophyton rubrum, confirmed by culture and DNA sequencing. Both patients had concomitant onychomycosis, and both were treated with itraconazole for about two months, which was interrupted due to pharmacological interactions with the immunosuppressive drugs and switched to terbinafine, leading to clinical resolution within four months. Deep dermatophytosis should be considered when dealing with immunocompromised patients, especially when a superficial dermatophytosis is present. Oral treatment is necessary and terbinafine is a preferable option in solid organ transplant recipients because it has less pharmacological interactions.Sociedade Brasileira de Dermatologia2022-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200223Anais Brasileiros de Dermatologia v.97 n.2 2022reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2021.05.014info:eu-repo/semantics/openAccessSilva,LeandroSousa,JoãoToscano,CristinaViana,Isabeleng2022-04-18T00:00:00Zoai:scielo:S0365-05962022000200223Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2022-04-18T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
title |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
spellingShingle |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients Silva,Leandro Dermatofitose Immunosuppression Transplant Trichophyton |
title_short |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
title_full |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
title_fullStr |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
title_full_unstemmed |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
title_sort |
Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients |
author |
Silva,Leandro |
author_facet |
Silva,Leandro Sousa,João Toscano,Cristina Viana,Isabel |
author_role |
author |
author2 |
Sousa,João Toscano,Cristina Viana,Isabel |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva,Leandro Sousa,João Toscano,Cristina Viana,Isabel |
dc.subject.por.fl_str_mv |
Dermatofitose Immunosuppression Transplant Trichophyton |
topic |
Dermatofitose Immunosuppression Transplant Trichophyton |
description |
Abstract In immunosuppressed patients, dermatophytosis can be more invasive, affecting the dermis and subcutaneous tissues. The authors describe the cases of two patients with kidney and heart transplanted, respectively, that developed a deep dermatophytosis caused by Trichophyton rubrum, confirmed by culture and DNA sequencing. Both patients had concomitant onychomycosis, and both were treated with itraconazole for about two months, which was interrupted due to pharmacological interactions with the immunosuppressive drugs and switched to terbinafine, leading to clinical resolution within four months. Deep dermatophytosis should be considered when dealing with immunocompromised patients, especially when a superficial dermatophytosis is present. Oral treatment is necessary and terbinafine is a preferable option in solid organ transplant recipients because it has less pharmacological interactions. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200223 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000200223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.abd.2021.05.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.97 n.2 2022 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126424678924288 |