Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865 |
Resumo: | Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal. |
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Anais brasileiros de dermatologia (Online) |
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Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatmentCeliac diseaseDapsoneDermatitis herpetiformisDiet, gluten-freeTransglutaminasesResearches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal.Sociedade Brasileira de Dermatologia2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865Anais Brasileiros de Dermatologia v.89 n.6 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20142966info:eu-repo/semantics/openAccessClarindo,Marcos ViníciusPossebon,Adriana TomazzoniSoligo,Emylle MarleneUyeda,HirofumiRuaro,Roseli TerezinhaEmpinotti,Julio Cesareng2015-03-25T00:00:00Zoai:scielo:S0365-05962014000600865Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2015-03-25T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
title |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
spellingShingle |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment Clarindo,Marcos Vinícius Celiac disease Dapsone Dermatitis herpetiformis Diet, gluten-free Transglutaminases |
title_short |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
title_full |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
title_fullStr |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
title_full_unstemmed |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
title_sort |
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment |
author |
Clarindo,Marcos Vinícius |
author_facet |
Clarindo,Marcos Vinícius Possebon,Adriana Tomazzoni Soligo,Emylle Marlene Uyeda,Hirofumi Ruaro,Roseli Terezinha Empinotti,Julio Cesar |
author_role |
author |
author2 |
Possebon,Adriana Tomazzoni Soligo,Emylle Marlene Uyeda,Hirofumi Ruaro,Roseli Terezinha Empinotti,Julio Cesar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Clarindo,Marcos Vinícius Possebon,Adriana Tomazzoni Soligo,Emylle Marlene Uyeda,Hirofumi Ruaro,Roseli Terezinha Empinotti,Julio Cesar |
dc.subject.por.fl_str_mv |
Celiac disease Dapsone Dermatitis herpetiformis Diet, gluten-free Transglutaminases |
topic |
Celiac disease Dapsone Dermatitis herpetiformis Diet, gluten-free Transglutaminases |
description |
Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20142966 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.89 n.6 2014 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126419898466304 |