Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment

Detalhes bibliográficos
Autor(a) principal: Clarindo,Marcos Vinícius
Data de Publicação: 2014
Outros Autores: Possebon,Adriana Tomazzoni, Soligo,Emylle Marlene, Uyeda,Hirofumi, Ruaro,Roseli Terezinha, Empinotti,Julio Cesar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865
Resumo: Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal.
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spelling Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatmentCeliac diseaseDapsoneDermatitis herpetiformisDiet, gluten-freeTransglutaminasesResearches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal.Sociedade Brasileira de Dermatologia2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865Anais Brasileiros de Dermatologia v.89 n.6 2014reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20142966info:eu-repo/semantics/openAccessClarindo,Marcos ViníciusPossebon,Adriana TomazzoniSoligo,Emylle MarleneUyeda,HirofumiRuaro,Roseli TerezinhaEmpinotti,Julio Cesareng2015-03-25T00:00:00Zoai:scielo:S0365-05962014000600865Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2015-03-25T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
title Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
spellingShingle Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
Clarindo,Marcos Vinícius
Celiac disease
Dapsone
Dermatitis herpetiformis
Diet, gluten-free
Transglutaminases
title_short Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
title_full Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
title_fullStr Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
title_full_unstemmed Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
title_sort Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment
author Clarindo,Marcos Vinícius
author_facet Clarindo,Marcos Vinícius
Possebon,Adriana Tomazzoni
Soligo,Emylle Marlene
Uyeda,Hirofumi
Ruaro,Roseli Terezinha
Empinotti,Julio Cesar
author_role author
author2 Possebon,Adriana Tomazzoni
Soligo,Emylle Marlene
Uyeda,Hirofumi
Ruaro,Roseli Terezinha
Empinotti,Julio Cesar
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Clarindo,Marcos Vinícius
Possebon,Adriana Tomazzoni
Soligo,Emylle Marlene
Uyeda,Hirofumi
Ruaro,Roseli Terezinha
Empinotti,Julio Cesar
dc.subject.por.fl_str_mv Celiac disease
Dapsone
Dermatitis herpetiformis
Diet, gluten-free
Transglutaminases
topic Celiac disease
Dapsone
Dermatitis herpetiformis
Diet, gluten-free
Transglutaminases
description Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to gluten is the starting point of an inflammatory cascade capable of forming autoantibodies that are brought to the skin, where they are deposited, culminating in the formation of skin lesions. These lesions are vesico-bullous, pruritic, and localized especially on elbows, knees and buttocks, although atypical presentations can occur. Immunofluorescence of perilesional area is considered the gold standard for diagnosis, but serological tests help in cases where it is negative. Patients who follow glutenfree diets have better control of symptoms on the skin and intestine, as well as lower risks of progression to lymphoma. Dapsone remains the main drug for treatment, but it requires monitoring of possible side effects, some potentially lethal.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600865
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20142966
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.89 n.6 2014
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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