Primary cutaneous anaplastic large-cell lymphoma - case report

• Autor(a) principal: Oliveira,Luciana Silveira Rabello de
• Data de Publicação: 2013
• Outros Autores: Nobrega,Madeleyne Palhano, Monteiro,Maira Gomes, Almeida,Wagner Leite de
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Anais brasileiros de dermatologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000800132
• topic: Lymphoma, large-cell, anaplastic; Lymphoma, primary cutaneous anaplastic large cell; Lymphoma, T-cell; Lymphoma, T-cell, cutaneous

Primary cutaneous anaplastic large-cell lymphoma is part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination may occur, especially to regional lymph nodes. Histology shows a diffuse, non-epidermotropic infiltrate , anaplastic large lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is good and does not depend on lymphatic invasion. Radiotherapy, removal of the lesion and/or low-dose methotrexate are the treatments of choice. The present study reports the case of a 57-year-old-woman presenting Primary cutaneous anaplastic large-cell lymphoma with multifocal lesions. The pacient evolved with pulmonary involvement 7 years later. She showed a good response to the treatment with low-dose methotrexate prescribed weekly.