Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face

Detalhes bibliográficos
Autor(a) principal: Henriques,Águida Cristina Gomes
Data de Publicação: 2016
Outros Autores: Freitas,Roseana de Almeida, Pires,Bruno Cunha, Gurgel,Clarissa Araújo, Santos,Jean Nunes dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500589
Resumo: Abstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results: The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion: These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.
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spelling Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the faceCollagenElastinImmunohistochemistryMast cellsAbstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results: The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion: These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.Sociedade Brasileira de Dermatologia2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500589Anais Brasileiros de Dermatologia v.91 n.5 2016reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20165077info:eu-repo/semantics/openAccessHenriques,Águida Cristina GomesFreitas,Roseana de AlmeidaPires,Bruno CunhaGurgel,Clarissa AraújoSantos,Jean Nunes doseng2016-11-04T00:00:00Zoai:scielo:S0365-05962016000500589Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2016-11-04T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
title Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
spellingShingle Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
Henriques,Águida Cristina Gomes
Collagen
Elastin
Immunohistochemistry
Mast cells
title_short Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
title_full Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
title_fullStr Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
title_full_unstemmed Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
title_sort Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
author Henriques,Águida Cristina Gomes
author_facet Henriques,Águida Cristina Gomes
Freitas,Roseana de Almeida
Pires,Bruno Cunha
Gurgel,Clarissa Araújo
Santos,Jean Nunes dos
author_role author
author2 Freitas,Roseana de Almeida
Pires,Bruno Cunha
Gurgel,Clarissa Araújo
Santos,Jean Nunes dos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Henriques,Águida Cristina Gomes
Freitas,Roseana de Almeida
Pires,Bruno Cunha
Gurgel,Clarissa Araújo
Santos,Jean Nunes dos
dc.subject.por.fl_str_mv Collagen
Elastin
Immunohistochemistry
Mast cells
topic Collagen
Elastin
Immunohistochemistry
Mast cells
description Abstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Methods: Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. Results: The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. Conclusion: These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500589
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500589
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20165077
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.91 n.5 2016
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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