Prognosis of patients with systemic lupus erythematosus and discoid lesions

Detalhes bibliográficos
Autor(a) principal: Skare,Thelma Larocca
Data de Publicação: 2013
Outros Autores: Stadler,Barbara, Weingraber,Emilio, De Paula,Diogo F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755
Resumo: BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP.
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spelling Prognosis of patients with systemic lupus erythematosus and discoid lesionsGlomerulonephritisLupus erythematosus, cutaneousLupus erythematosus, discoidLupus erythematosus, systemicGlomerulonefriteLupus eritematoso cutaneoLupus eritematoso discoideLupus eritematoso sistemico BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP. Sociedade Brasileira de Dermatologia2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755Anais Brasileiros de Dermatologia v.88 n.5 2013reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20132042info:eu-repo/semantics/openAccessSkare,Thelma LaroccaStadler,BarbaraWeingraber,EmilioDe Paula,Diogo F.eng2013-10-28T00:00:00Zoai:scielo:S0365-05962013000500755Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2013-10-28T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Prognosis of patients with systemic lupus erythematosus and discoid lesions
title Prognosis of patients with systemic lupus erythematosus and discoid lesions
spellingShingle Prognosis of patients with systemic lupus erythematosus and discoid lesions
Skare,Thelma Larocca
Glomerulonephritis
Lupus erythematosus, cutaneous
Lupus erythematosus, discoid
Lupus erythematosus, systemic
Glomerulonefrite
Lupus eritematoso cutaneo
Lupus eritematoso discoide
Lupus eritematoso sistemico
title_short Prognosis of patients with systemic lupus erythematosus and discoid lesions
title_full Prognosis of patients with systemic lupus erythematosus and discoid lesions
title_fullStr Prognosis of patients with systemic lupus erythematosus and discoid lesions
title_full_unstemmed Prognosis of patients with systemic lupus erythematosus and discoid lesions
title_sort Prognosis of patients with systemic lupus erythematosus and discoid lesions
author Skare,Thelma Larocca
author_facet Skare,Thelma Larocca
Stadler,Barbara
Weingraber,Emilio
De Paula,Diogo F.
author_role author
author2 Stadler,Barbara
Weingraber,Emilio
De Paula,Diogo F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Skare,Thelma Larocca
Stadler,Barbara
Weingraber,Emilio
De Paula,Diogo F.
dc.subject.por.fl_str_mv Glomerulonephritis
Lupus erythematosus, cutaneous
Lupus erythematosus, discoid
Lupus erythematosus, systemic
Glomerulonefrite
Lupus eritematoso cutaneo
Lupus eritematoso discoide
Lupus eritematoso sistemico
topic Glomerulonephritis
Lupus erythematosus, cutaneous
Lupus erythematosus, discoid
Lupus erythematosus, systemic
Glomerulonefrite
Lupus eritematoso cutaneo
Lupus eritematoso discoide
Lupus eritematoso sistemico
description BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20132042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.88 n.5 2013
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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