Prognosis of patients with systemic lupus erythematosus and discoid lesions
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755 |
Resumo: | BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP. |
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Anais brasileiros de dermatologia (Online) |
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Prognosis of patients with systemic lupus erythematosus and discoid lesionsGlomerulonephritisLupus erythematosus, cutaneousLupus erythematosus, discoidLupus erythematosus, systemicGlomerulonefriteLupus eritematoso cutaneoLupus eritematoso discoideLupus eritematoso sistemico BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP. Sociedade Brasileira de Dermatologia2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755Anais Brasileiros de Dermatologia v.88 n.5 2013reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20132042info:eu-repo/semantics/openAccessSkare,Thelma LaroccaStadler,BarbaraWeingraber,EmilioDe Paula,Diogo F.eng2013-10-28T00:00:00Zoai:scielo:S0365-05962013000500755Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2013-10-28T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
title |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
spellingShingle |
Prognosis of patients with systemic lupus erythematosus and discoid lesions Skare,Thelma Larocca Glomerulonephritis Lupus erythematosus, cutaneous Lupus erythematosus, discoid Lupus erythematosus, systemic Glomerulonefrite Lupus eritematoso cutaneo Lupus eritematoso discoide Lupus eritematoso sistemico |
title_short |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
title_full |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
title_fullStr |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
title_full_unstemmed |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
title_sort |
Prognosis of patients with systemic lupus erythematosus and discoid lesions |
author |
Skare,Thelma Larocca |
author_facet |
Skare,Thelma Larocca Stadler,Barbara Weingraber,Emilio De Paula,Diogo F. |
author_role |
author |
author2 |
Stadler,Barbara Weingraber,Emilio De Paula,Diogo F. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Skare,Thelma Larocca Stadler,Barbara Weingraber,Emilio De Paula,Diogo F. |
dc.subject.por.fl_str_mv |
Glomerulonephritis Lupus erythematosus, cutaneous Lupus erythematosus, discoid Lupus erythematosus, systemic Glomerulonefrite Lupus eritematoso cutaneo Lupus eritematoso discoide Lupus eritematoso sistemico |
topic |
Glomerulonephritis Lupus erythematosus, cutaneous Lupus erythematosus, discoid Lupus erythematosus, systemic Glomerulonefrite Lupus eritematoso cutaneo Lupus eritematoso discoide Lupus eritematoso sistemico |
description |
BACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500755 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20132042 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.88 n.5 2013 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126419032342528 |