Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000100206 |
Resumo: | ABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction. |
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Acta Cirúrgica Brasileira (Online) |
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Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?CreatinineIntracranial AneurysmGlomerular Filtration RateABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000100206Acta Cirúrgica Brasileira v.37 n.1 2022reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/acb370107info:eu-repo/semantics/openAccessRabelo,Nícollas NunesPipek,Leonardo ZumerkornNascimento,Rafaela Farias VidigalTelles,João Paulo MotaBarbato,Natalia CamargoCoelho,Antônio Carlos Samaia da SilvaBarbosa,Guilherme BitencourtYoshikawa,Marcia HarumyTeixeira,Manoel JacobsenFigueiredo,Eberval Gadelhaeng2022-04-05T00:00:00Zoai:scielo:S0102-86502022000100206Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2022-04-05T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
title |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
spellingShingle |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? Rabelo,Nícollas Nunes Creatinine Intracranial Aneurysm Glomerular Filtration Rate |
title_short |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
title_full |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
title_fullStr |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
title_full_unstemmed |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
title_sort |
Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate? |
author |
Rabelo,Nícollas Nunes |
author_facet |
Rabelo,Nícollas Nunes Pipek,Leonardo Zumerkorn Nascimento,Rafaela Farias Vidigal Telles,João Paulo Mota Barbato,Natalia Camargo Coelho,Antônio Carlos Samaia da Silva Barbosa,Guilherme Bitencourt Yoshikawa,Marcia Harumy Teixeira,Manoel Jacobsen Figueiredo,Eberval Gadelha |
author_role |
author |
author2 |
Pipek,Leonardo Zumerkorn Nascimento,Rafaela Farias Vidigal Telles,João Paulo Mota Barbato,Natalia Camargo Coelho,Antônio Carlos Samaia da Silva Barbosa,Guilherme Bitencourt Yoshikawa,Marcia Harumy Teixeira,Manoel Jacobsen Figueiredo,Eberval Gadelha |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rabelo,Nícollas Nunes Pipek,Leonardo Zumerkorn Nascimento,Rafaela Farias Vidigal Telles,João Paulo Mota Barbato,Natalia Camargo Coelho,Antônio Carlos Samaia da Silva Barbosa,Guilherme Bitencourt Yoshikawa,Marcia Harumy Teixeira,Manoel Jacobsen Figueiredo,Eberval Gadelha |
dc.subject.por.fl_str_mv |
Creatinine Intracranial Aneurysm Glomerular Filtration Rate |
topic |
Creatinine Intracranial Aneurysm Glomerular Filtration Rate |
description |
ABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000100206 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000100206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/acb370107 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.37 n.1 2022 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126446355087360 |