Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500328 |
Resumo: | PURPOSE:To investigate diclofenac topical gel as an alternative to reduce phlogistic signals and maintain quality of wound repair.METHODS:Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, cranial wounds received topical diclofenac gel administration and caudal wounds were washed with isotonic saline. After seven, 14 and 21 postoperative days, five animals were randomly chosen for macroscopic and microscopic wound analysis.RESULTS:On the 7th day: diclofenac wounds showed significant higher scab formation, however showed less phlogistic signal; diclofenac wounds had larger area and had less neutrophil invasion. On the 14th day: No area difference was noted and diclofenac wounds showed less hyperemia and phlogistic signals; diclofenac wounds showed greater keratinocytes invasion. On the 21st day: Almost all wounds were closed and there were no difference regarding the type of scar formation; diclofenac wounds showed greater monocytes invasion and lower angiogenesis level. No difference was noted in any postoperative day regarding fibroblast invasion, collagen deposit quantity and quality.CONCLUSION: Diclofenac topical gel is capable of reducing phlogistic signals and do not cause fibroblast or keratinocyte downregulation thus do not lead to excisional wound healing impairment. |
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Acta Cirúrgica Brasileira (Online) |
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Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1Wound HealingRegenerationCicatrixDiclofenacRatsPURPOSE:To investigate diclofenac topical gel as an alternative to reduce phlogistic signals and maintain quality of wound repair.METHODS:Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, cranial wounds received topical diclofenac gel administration and caudal wounds were washed with isotonic saline. After seven, 14 and 21 postoperative days, five animals were randomly chosen for macroscopic and microscopic wound analysis.RESULTS:On the 7th day: diclofenac wounds showed significant higher scab formation, however showed less phlogistic signal; diclofenac wounds had larger area and had less neutrophil invasion. On the 14th day: No area difference was noted and diclofenac wounds showed less hyperemia and phlogistic signals; diclofenac wounds showed greater keratinocytes invasion. On the 21st day: Almost all wounds were closed and there were no difference regarding the type of scar formation; diclofenac wounds showed greater monocytes invasion and lower angiogenesis level. No difference was noted in any postoperative day regarding fibroblast invasion, collagen deposit quantity and quality.CONCLUSION: Diclofenac topical gel is capable of reducing phlogistic signals and do not cause fibroblast or keratinocyte downregulation thus do not lead to excisional wound healing impairment.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500328Acta Cirúrgica Brasileira v.29 n.5 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000500007info:eu-repo/semantics/openAccessCosta,Felipe Lobato da SilvaTiussi,Laila DepráNascimento,Mayara SilvaCorrêa,Antonio Carlos de SouzaYasojima,Edson YuzurPires,Carla Andréa Avelareng2015-10-08T00:00:00Zoai:scielo:S0102-86502014000500328Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-08T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
title |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
spellingShingle |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 Costa,Felipe Lobato da Silva Wound Healing Regeneration Cicatrix Diclofenac Rats |
title_short |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
title_full |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
title_fullStr |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
title_full_unstemmed |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
title_sort |
Diclofenac topical gel in excisional wounds maintain heal quality and reduce phlogistic signals1 |
author |
Costa,Felipe Lobato da Silva |
author_facet |
Costa,Felipe Lobato da Silva Tiussi,Laila Deprá Nascimento,Mayara Silva Corrêa,Antonio Carlos de Souza Yasojima,Edson Yuzur Pires,Carla Andréa Avelar |
author_role |
author |
author2 |
Tiussi,Laila Deprá Nascimento,Mayara Silva Corrêa,Antonio Carlos de Souza Yasojima,Edson Yuzur Pires,Carla Andréa Avelar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Costa,Felipe Lobato da Silva Tiussi,Laila Deprá Nascimento,Mayara Silva Corrêa,Antonio Carlos de Souza Yasojima,Edson Yuzur Pires,Carla Andréa Avelar |
dc.subject.por.fl_str_mv |
Wound Healing Regeneration Cicatrix Diclofenac Rats |
topic |
Wound Healing Regeneration Cicatrix Diclofenac Rats |
description |
PURPOSE:To investigate diclofenac topical gel as an alternative to reduce phlogistic signals and maintain quality of wound repair.METHODS:Fifteen Wistar rats were used in this study; four excisional wounds were performed on the dorsum of each animal. Once in a day, cranial wounds received topical diclofenac gel administration and caudal wounds were washed with isotonic saline. After seven, 14 and 21 postoperative days, five animals were randomly chosen for macroscopic and microscopic wound analysis.RESULTS:On the 7th day: diclofenac wounds showed significant higher scab formation, however showed less phlogistic signal; diclofenac wounds had larger area and had less neutrophil invasion. On the 14th day: No area difference was noted and diclofenac wounds showed less hyperemia and phlogistic signals; diclofenac wounds showed greater keratinocytes invasion. On the 21st day: Almost all wounds were closed and there were no difference regarding the type of scar formation; diclofenac wounds showed greater monocytes invasion and lower angiogenesis level. No difference was noted in any postoperative day regarding fibroblast invasion, collagen deposit quantity and quality.CONCLUSION: Diclofenac topical gel is capable of reducing phlogistic signals and do not cause fibroblast or keratinocyte downregulation thus do not lead to excisional wound healing impairment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500328 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000500328 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502014000500007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.5 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442283466752 |