Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction

Detalhes bibliográficos
Autor(a) principal: Maldonado-Menetti,Julianne dos Santos
Data de Publicação: 2016
Outros Autores: Vitor,Taise, Edelmuth,Rodrigo Camargo Leão, Ferrante,Fernanda Amá, Souza,Pamella Ramona de Moraes, Koike,Marcia Kiyomi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000300190
Resumo: ABSTRACT PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups. RESULTS: Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium. CONCLUSION: Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.
id SBDPC-1_07008332f62c5a72811ac0582629ca15
oai_identifier_str oai:scielo:S0102-86502016000300190
network_acronym_str SBDPC-1
network_name_str Acta Cirúrgica Brasileira (Online)
repository_id_str
spelling Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarctionMyocardial Infarction. Ventricular Remodeling. Fatty AcidsOmega-6. RatsABSTRACT PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups. RESULTS: Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium. CONCLUSION: Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000300190Acta Cirúrgica Brasileira v.31 n.3 2016reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-865020160030000007info:eu-repo/semantics/openAccessMaldonado-Menetti,Julianne dos SantosVitor,TaiseEdelmuth,Rodrigo Camargo LeãoFerrante,Fernanda AmáSouza,Pamella Ramona de MoraesKoike,Marcia Kiyomieng2016-05-06T00:00:00Zoai:scielo:S0102-86502016000300190Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2016-05-06T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
title Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
spellingShingle Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
Maldonado-Menetti,Julianne dos Santos
Myocardial Infarction. Ventricular Remodeling. Fatty Acids
Omega-6. Rats
title_short Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
title_full Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
title_fullStr Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
title_full_unstemmed Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
title_sort Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
author Maldonado-Menetti,Julianne dos Santos
author_facet Maldonado-Menetti,Julianne dos Santos
Vitor,Taise
Edelmuth,Rodrigo Camargo Leão
Ferrante,Fernanda Amá
Souza,Pamella Ramona de Moraes
Koike,Marcia Kiyomi
author_role author
author2 Vitor,Taise
Edelmuth,Rodrigo Camargo Leão
Ferrante,Fernanda Amá
Souza,Pamella Ramona de Moraes
Koike,Marcia Kiyomi
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Maldonado-Menetti,Julianne dos Santos
Vitor,Taise
Edelmuth,Rodrigo Camargo Leão
Ferrante,Fernanda Amá
Souza,Pamella Ramona de Moraes
Koike,Marcia Kiyomi
dc.subject.por.fl_str_mv Myocardial Infarction. Ventricular Remodeling. Fatty Acids
Omega-6. Rats
topic Myocardial Infarction. Ventricular Remodeling. Fatty Acids
Omega-6. Rats
description ABSTRACT PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups. RESULTS: Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium. CONCLUSION: Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000300190
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000300190
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-865020160030000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.31 n.3 2016
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
_version_ 1752126443614109696

Registros relacionados