Effects of chitosan on healing and strength of colonic anastomosis in rats

Detalhes bibliográficos
Autor(a) principal: Citgez,Bulent
Data de Publicação: 2012
Outros Autores: Cengiz,Ahmet Nurettin, Akgun,Ismail, Uludag,Mehmet, Yetkin,Gurkan, Bahat,Neslihan, Ozcan,Omer, Polat,Nedim, Akcakaya,Adem, Karatepe,Oguzhan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
Resumo: PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.
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spelling Effects of chitosan on healing and strength of colonic anastomosis in ratsChitosanAnastomosis, SurgicalTensile StrengthWound HealingRatsPURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007Acta Cirúrgica Brasileira v.27 n.10 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012001000007info:eu-repo/semantics/openAccessCitgez,BulentCengiz,Ahmet NurettinAkgun,IsmailUludag,MehmetYetkin,GurkanBahat,NeslihanOzcan,OmerPolat,NedimAkcakaya,AdemKaratepe,Oguzhaneng2012-09-27T00:00:00Zoai:scielo:S0102-86502012001000007Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-09-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Effects of chitosan on healing and strength of colonic anastomosis in rats
title Effects of chitosan on healing and strength of colonic anastomosis in rats
spellingShingle Effects of chitosan on healing and strength of colonic anastomosis in rats
Citgez,Bulent
Chitosan
Anastomosis, Surgical
Tensile Strength
Wound Healing
Rats
title_short Effects of chitosan on healing and strength of colonic anastomosis in rats
title_full Effects of chitosan on healing and strength of colonic anastomosis in rats
title_fullStr Effects of chitosan on healing and strength of colonic anastomosis in rats
title_full_unstemmed Effects of chitosan on healing and strength of colonic anastomosis in rats
title_sort Effects of chitosan on healing and strength of colonic anastomosis in rats
author Citgez,Bulent
author_facet Citgez,Bulent
Cengiz,Ahmet Nurettin
Akgun,Ismail
Uludag,Mehmet
Yetkin,Gurkan
Bahat,Neslihan
Ozcan,Omer
Polat,Nedim
Akcakaya,Adem
Karatepe,Oguzhan
author_role author
author2 Cengiz,Ahmet Nurettin
Akgun,Ismail
Uludag,Mehmet
Yetkin,Gurkan
Bahat,Neslihan
Ozcan,Omer
Polat,Nedim
Akcakaya,Adem
Karatepe,Oguzhan
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Citgez,Bulent
Cengiz,Ahmet Nurettin
Akgun,Ismail
Uludag,Mehmet
Yetkin,Gurkan
Bahat,Neslihan
Ozcan,Omer
Polat,Nedim
Akcakaya,Adem
Karatepe,Oguzhan
dc.subject.por.fl_str_mv Chitosan
Anastomosis, Surgical
Tensile Strength
Wound Healing
Rats
topic Chitosan
Anastomosis, Surgical
Tensile Strength
Wound Healing
Rats
description PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012001000007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012001000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.10 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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