An experimental model for the study of craniofacial deformities

Detalhes bibliográficos
Autor(a) principal: Costa,André de Mendonça
Data de Publicação: 2010
Outros Autores: Kobayashi,Gerson Shigeru, Bueno,Daniela Franco, Martins,Marília Trierveiler, Ferreira,Marcus de Castro, Passos-Bueno,Maria Rita, Alonso,Nivaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300008
Resumo: PURPOSE: To develop an experimental surgical model in rats for the study of craniofacial abnormalities. METHODS: Full thickness calvarial defects with 10x10-mm and 5x8-mm dimensions were created in 40 male NIS Wistar rats, body weight ranging from 320 to 420 g. The animals were equally divided into two groups. The periosteum was removed and dura mater was left intact. Animals were killed at 8 and 16 weeks postoperatively and cranial tissue samples were taken from the defects for histological analysis. RESULTS: Cranial defects remained open even after 16 weeks postoperatively. CONCLUSION: The experimental model with 5x8-mm defects in the parietal region with the removal of the periosteum and maintenance of the integrity of the dura mater are critical and might be used for the study of cranial bone defects in craniofacial abnormalities.
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spelling An experimental model for the study of craniofacial deformitiesBone RegenerationCraniofacial AbnormalitiesParietal BoneRatsPURPOSE: To develop an experimental surgical model in rats for the study of craniofacial abnormalities. METHODS: Full thickness calvarial defects with 10x10-mm and 5x8-mm dimensions were created in 40 male NIS Wistar rats, body weight ranging from 320 to 420 g. The animals were equally divided into two groups. The periosteum was removed and dura mater was left intact. Animals were killed at 8 and 16 weeks postoperatively and cranial tissue samples were taken from the defects for histological analysis. RESULTS: Cranial defects remained open even after 16 weeks postoperatively. CONCLUSION: The experimental model with 5x8-mm defects in the parietal region with the removal of the periosteum and maintenance of the integrity of the dura mater are critical and might be used for the study of cranial bone defects in craniofacial abnormalities.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300008Acta Cirúrgica Brasileira v.25 n.3 2010reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502010000300008info:eu-repo/semantics/openAccessCosta,André de MendonçaKobayashi,Gerson ShigeruBueno,Daniela FrancoMartins,Marília TrierveilerFerreira,Marcus de CastroPassos-Bueno,Maria RitaAlonso,Nivaldoeng2010-05-21T00:00:00Zoai:scielo:S0102-86502010000300008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2010-05-21T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv An experimental model for the study of craniofacial deformities
title An experimental model for the study of craniofacial deformities
spellingShingle An experimental model for the study of craniofacial deformities
Costa,André de Mendonça
Bone Regeneration
Craniofacial Abnormalities
Parietal Bone
Rats
title_short An experimental model for the study of craniofacial deformities
title_full An experimental model for the study of craniofacial deformities
title_fullStr An experimental model for the study of craniofacial deformities
title_full_unstemmed An experimental model for the study of craniofacial deformities
title_sort An experimental model for the study of craniofacial deformities
author Costa,André de Mendonça
author_facet Costa,André de Mendonça
Kobayashi,Gerson Shigeru
Bueno,Daniela Franco
Martins,Marília Trierveiler
Ferreira,Marcus de Castro
Passos-Bueno,Maria Rita
Alonso,Nivaldo
author_role author
author2 Kobayashi,Gerson Shigeru
Bueno,Daniela Franco
Martins,Marília Trierveiler
Ferreira,Marcus de Castro
Passos-Bueno,Maria Rita
Alonso,Nivaldo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa,André de Mendonça
Kobayashi,Gerson Shigeru
Bueno,Daniela Franco
Martins,Marília Trierveiler
Ferreira,Marcus de Castro
Passos-Bueno,Maria Rita
Alonso,Nivaldo
dc.subject.por.fl_str_mv Bone Regeneration
Craniofacial Abnormalities
Parietal Bone
Rats
topic Bone Regeneration
Craniofacial Abnormalities
Parietal Bone
Rats
description PURPOSE: To develop an experimental surgical model in rats for the study of craniofacial abnormalities. METHODS: Full thickness calvarial defects with 10x10-mm and 5x8-mm dimensions were created in 40 male NIS Wistar rats, body weight ranging from 320 to 420 g. The animals were equally divided into two groups. The periosteum was removed and dura mater was left intact. Animals were killed at 8 and 16 weeks postoperatively and cranial tissue samples were taken from the defects for histological analysis. RESULTS: Cranial defects remained open even after 16 weeks postoperatively. CONCLUSION: The experimental model with 5x8-mm defects in the parietal region with the removal of the periosteum and maintenance of the integrity of the dura mater are critical and might be used for the study of cranial bone defects in craniofacial abnormalities.
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502010000300008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.25 n.3 2010
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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