Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats

Detalhes bibliográficos
Autor(a) principal: Barros,Pedro Paulo
Data de Publicação: 2017
Outros Autores: Gonçalves,Gisele Mara Silva, Silva,Gustavo Henrique da, Bastos,Maria Clara Villaça Dias, Ramos,Loren Nogaroto, Fernandes,Marilia Marinello
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194
Resumo: Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.
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spelling Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized ratsAlanine TransaminaseAspartate AminotransferasesApoptosisMitotic IndexRats.Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194Acta Cirúrgica Brasileira v.32 n.3 2017reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020170030000003info:eu-repo/semantics/openAccessBarros,Pedro PauloGonçalves,Gisele Mara SilvaSilva,Gustavo Henrique daBastos,Maria Clara Villaça DiasRamos,Loren NogarotoFernandes,Marilia Marinelloeng2017-04-04T00:00:00Zoai:scielo:S0102-86502017000300194Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2017-04-04T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
title Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
spellingShingle Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
Barros,Pedro Paulo
Alanine Transaminase
Aspartate Aminotransferases
Apoptosis
Mitotic Index
Rats.
title_short Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
title_full Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
title_fullStr Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
title_full_unstemmed Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
title_sort Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
author Barros,Pedro Paulo
author_facet Barros,Pedro Paulo
Gonçalves,Gisele Mara Silva
Silva,Gustavo Henrique da
Bastos,Maria Clara Villaça Dias
Ramos,Loren Nogaroto
Fernandes,Marilia Marinello
author_role author
author2 Gonçalves,Gisele Mara Silva
Silva,Gustavo Henrique da
Bastos,Maria Clara Villaça Dias
Ramos,Loren Nogaroto
Fernandes,Marilia Marinello
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barros,Pedro Paulo
Gonçalves,Gisele Mara Silva
Silva,Gustavo Henrique da
Bastos,Maria Clara Villaça Dias
Ramos,Loren Nogaroto
Fernandes,Marilia Marinello
dc.subject.por.fl_str_mv Alanine Transaminase
Aspartate Aminotransferases
Apoptosis
Mitotic Index
Rats.
topic Alanine Transaminase
Aspartate Aminotransferases
Apoptosis
Mitotic Index
Rats.
description Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020170030000003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.32 n.3 2017
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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