New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

Detalhes bibliográficos
Autor(a) principal: Macêdo,Clóvis Ney Pinheiro
Data de Publicação: 2019
Outros Autores: Braga,Francisco Evanilso Silva, Campelo,Ana Paula Bomfim Soares, Diniz,Gabriel Maia, Lopes,Luiz Gonzaga de França, Kubrusly,Marcos, Campelo,Marcio Wilker Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001200210
Resumo: Abstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
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spelling New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatoryAnti-Inflammatory Agents, Non-SteroidalKidneyRutheniumRatsAbstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001200210Acta Cirúrgica Brasileira v.34 n.12 2019reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/s0102-865020190120000001info:eu-repo/semantics/openAccessMacêdo,Clóvis Ney PinheiroBraga,Francisco Evanilso SilvaCampelo,Ana Paula Bomfim SoaresDiniz,Gabriel MaiaLopes,Luiz Gonzaga de FrançaKubrusly,MarcosCampelo,Marcio Wilker Soareseng2020-01-31T00:00:00Zoai:scielo:S0102-86502019001200210Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2020-01-31T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
spellingShingle New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
Macêdo,Clóvis Ney Pinheiro
Anti-Inflammatory Agents, Non-Steroidal
Kidney
Ruthenium
Rats
title_short New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_full New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_fullStr New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_full_unstemmed New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
title_sort New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
author Macêdo,Clóvis Ney Pinheiro
author_facet Macêdo,Clóvis Ney Pinheiro
Braga,Francisco Evanilso Silva
Campelo,Ana Paula Bomfim Soares
Diniz,Gabriel Maia
Lopes,Luiz Gonzaga de França
Kubrusly,Marcos
Campelo,Marcio Wilker Soares
author_role author
author2 Braga,Francisco Evanilso Silva
Campelo,Ana Paula Bomfim Soares
Diniz,Gabriel Maia
Lopes,Luiz Gonzaga de França
Kubrusly,Marcos
Campelo,Marcio Wilker Soares
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macêdo,Clóvis Ney Pinheiro
Braga,Francisco Evanilso Silva
Campelo,Ana Paula Bomfim Soares
Diniz,Gabriel Maia
Lopes,Luiz Gonzaga de França
Kubrusly,Marcos
Campelo,Marcio Wilker Soares
dc.subject.por.fl_str_mv Anti-Inflammatory Agents, Non-Steroidal
Kidney
Ruthenium
Rats
topic Anti-Inflammatory Agents, Non-Steroidal
Kidney
Ruthenium
Rats
description Abstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001200210
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001200210
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0102-865020190120000001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.34 n.12 2019
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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