The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008 |
Resumo: | PURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis. |
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Acta Cirúrgica Brasileira (Online) |
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The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factorsFatty LiverObesity, MorbidBariatric SurgeryPURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008Acta Cirúrgica Brasileira v.28 n.11 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013001100008info:eu-repo/semantics/openAccessFeijó,Suerda GuiomarLima,José Milton de CastroOliveira,Maria Aparecida Alves dePatrocínio,Régia Maria VidalMoura-Junior,Luis GonzagaCampos,Antônio BorgesLima,José Wellington OliveiraBraga,Lúcia Libanez Bessa Campeloeng2013-12-05T00:00:00Zoai:scielo:S0102-86502013001100008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-12-05T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
title |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
spellingShingle |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors Feijó,Suerda Guiomar Fatty Liver Obesity, Morbid Bariatric Surgery |
title_short |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
title_full |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
title_fullStr |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
title_full_unstemmed |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
title_sort |
The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors |
author |
Feijó,Suerda Guiomar |
author_facet |
Feijó,Suerda Guiomar Lima,José Milton de Castro Oliveira,Maria Aparecida Alves de Patrocínio,Régia Maria Vidal Moura-Junior,Luis Gonzaga Campos,Antônio Borges Lima,José Wellington Oliveira Braga,Lúcia Libanez Bessa Campelo |
author_role |
author |
author2 |
Lima,José Milton de Castro Oliveira,Maria Aparecida Alves de Patrocínio,Régia Maria Vidal Moura-Junior,Luis Gonzaga Campos,Antônio Borges Lima,José Wellington Oliveira Braga,Lúcia Libanez Bessa Campelo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Feijó,Suerda Guiomar Lima,José Milton de Castro Oliveira,Maria Aparecida Alves de Patrocínio,Régia Maria Vidal Moura-Junior,Luis Gonzaga Campos,Antônio Borges Lima,José Wellington Oliveira Braga,Lúcia Libanez Bessa Campelo |
dc.subject.por.fl_str_mv |
Fatty Liver Obesity, Morbid Bariatric Surgery |
topic |
Fatty Liver Obesity, Morbid Bariatric Surgery |
description |
PURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502013001100008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.28 n.11 2013 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442142957568 |