The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors

Detalhes bibliográficos
Autor(a) principal: Feijó,Suerda Guiomar
Data de Publicação: 2013
Outros Autores: Lima,José Milton de Castro, Oliveira,Maria Aparecida Alves de, Patrocínio,Régia Maria Vidal, Moura-Junior,Luis Gonzaga, Campos,Antônio Borges, Lima,José Wellington Oliveira, Braga,Lúcia Libanez Bessa Campelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008
Resumo: PURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis.
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spelling The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factorsFatty LiverObesity, MorbidBariatric SurgeryPURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2013-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008Acta Cirúrgica Brasileira v.28 n.11 2013reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502013001100008info:eu-repo/semantics/openAccessFeijó,Suerda GuiomarLima,José Milton de CastroOliveira,Maria Aparecida Alves dePatrocínio,Régia Maria VidalMoura-Junior,Luis GonzagaCampos,Antônio BorgesLima,José Wellington OliveiraBraga,Lúcia Libanez Bessa Campeloeng2013-12-05T00:00:00Zoai:scielo:S0102-86502013001100008Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2013-12-05T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
title The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
spellingShingle The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
Feijó,Suerda Guiomar
Fatty Liver
Obesity, Morbid
Bariatric Surgery
title_short The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
title_full The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
title_fullStr The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
title_full_unstemmed The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
title_sort The spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors
author Feijó,Suerda Guiomar
author_facet Feijó,Suerda Guiomar
Lima,José Milton de Castro
Oliveira,Maria Aparecida Alves de
Patrocínio,Régia Maria Vidal
Moura-Junior,Luis Gonzaga
Campos,Antônio Borges
Lima,José Wellington Oliveira
Braga,Lúcia Libanez Bessa Campelo
author_role author
author2 Lima,José Milton de Castro
Oliveira,Maria Aparecida Alves de
Patrocínio,Régia Maria Vidal
Moura-Junior,Luis Gonzaga
Campos,Antônio Borges
Lima,José Wellington Oliveira
Braga,Lúcia Libanez Bessa Campelo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Feijó,Suerda Guiomar
Lima,José Milton de Castro
Oliveira,Maria Aparecida Alves de
Patrocínio,Régia Maria Vidal
Moura-Junior,Luis Gonzaga
Campos,Antônio Borges
Lima,José Wellington Oliveira
Braga,Lúcia Libanez Bessa Campelo
dc.subject.por.fl_str_mv Fatty Liver
Obesity, Morbid
Bariatric Surgery
topic Fatty Liver
Obesity, Morbid
Bariatric Surgery
description PURPOSE: To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS: Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, biochemical and histological features were evaluated. RESULTS: NAFLD was detected in fifty-seven patients (95%) of the sample and forty patients (66.7%) of the total sample met the criteria for NASH. Perisinusoidal fibrosis was only found in three (7.5%) patients with NASH. The γGT was an independent predictive factor associated with the degree of hepatic steatosis. The variables such as dyslipidemia and ALT were independently associated with the presence of Mallory's corpuscles with the following values, respectively, OR 0, 05, 95% CI 0.002 to 0.75, P = 0.031 and OR 10, 99, 95% CI 1.44 to 83.93, P = 0.021. CONCLUSIONS: Non alcoholic fatty liver disease seems to be an obese-related condition with approximately half of asymptomatic morbidly obese patients having histological NASH. The γGT was an independent predictor of the degree of steatosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502013001100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.28 n.11 2013
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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