COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS

Detalhes bibliográficos
Autor(a) principal: Ruiz Junior,Raul Lopes
Data de Publicação: 1998
Outros Autores: Burini,Roberto Carlos, Cataneo,Antonio José Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100003
Resumo: Aiming at assessing compensatory lung growth after trilobectomy in rats, 3 groups of animals (control, thoracotomy and trilobectomy) were studied over 3 time intervals (7, 30 and 180 days post-operation). Protein, DNA and RNA contents in each lung were evaluated. The study of the left lung protein content reveals that compensatory growth ceased by day 30, whereas it continued to occur in the cranial lobe as long as 180 days post-operation. The lung DNA content in trilobectomized animals remained smaller than in the animals of the other groups demonstrating that compensatory growth was not brought about by hyperplasia. The lung RNA content in trilobectomized animals increased similarly to the lung protein content, demonstrating that the cells of the lung tissue must have had an increase in volume as no significant increase in their number occurred, as shown by the analysis of the lung DNA content. Therefore, it may be concluded that, in our experiment with adult animals, compensatory lung growth after trilobectomy in rats occurred due to an increase in the lung protein content and RNA content, suggesting a cellular volume increase (hypertrophy) and a probable increase in the intralveolar septs rather than an important cell multiplication
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spelling COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATSCompensatory GrowthLungProtein ContentDNA ContentRNA ContentTrilobectomyAiming at assessing compensatory lung growth after trilobectomy in rats, 3 groups of animals (control, thoracotomy and trilobectomy) were studied over 3 time intervals (7, 30 and 180 days post-operation). Protein, DNA and RNA contents in each lung were evaluated. The study of the left lung protein content reveals that compensatory growth ceased by day 30, whereas it continued to occur in the cranial lobe as long as 180 days post-operation. The lung DNA content in trilobectomized animals remained smaller than in the animals of the other groups demonstrating that compensatory growth was not brought about by hyperplasia. The lung RNA content in trilobectomized animals increased similarly to the lung protein content, demonstrating that the cells of the lung tissue must have had an increase in volume as no significant increase in their number occurred, as shown by the analysis of the lung DNA content. Therefore, it may be concluded that, in our experiment with adult animals, compensatory lung growth after trilobectomy in rats occurred due to an increase in the lung protein content and RNA content, suggesting a cellular volume increase (hypertrophy) and a probable increase in the intralveolar septs rather than an important cell multiplicationSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100003Acta Cirúrgica Brasileira v.13 n.1 1998reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86501998000100003info:eu-repo/semantics/openAccessRuiz Junior,Raul LopesBurini,Roberto CarlosCataneo,Antonio José Mariaeng1998-11-18T00:00:00Zoai:scielo:S0102-86501998000100003Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:1998-11-18T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
title COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
spellingShingle COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
Ruiz Junior,Raul Lopes
Compensatory Growth
Lung
Protein Content
DNA Content
RNA Content
Trilobectomy
title_short COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
title_full COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
title_fullStr COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
title_full_unstemmed COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
title_sort COMPENSATORY LUNG GROWTH: LUNG PROTEIN,DNA AND RNA CONTENTS IN TRILOBECTOMIZED RATS
author Ruiz Junior,Raul Lopes
author_facet Ruiz Junior,Raul Lopes
Burini,Roberto Carlos
Cataneo,Antonio José Maria
author_role author
author2 Burini,Roberto Carlos
Cataneo,Antonio José Maria
author2_role author
author
dc.contributor.author.fl_str_mv Ruiz Junior,Raul Lopes
Burini,Roberto Carlos
Cataneo,Antonio José Maria
dc.subject.por.fl_str_mv Compensatory Growth
Lung
Protein Content
DNA Content
RNA Content
Trilobectomy
topic Compensatory Growth
Lung
Protein Content
DNA Content
RNA Content
Trilobectomy
description Aiming at assessing compensatory lung growth after trilobectomy in rats, 3 groups of animals (control, thoracotomy and trilobectomy) were studied over 3 time intervals (7, 30 and 180 days post-operation). Protein, DNA and RNA contents in each lung were evaluated. The study of the left lung protein content reveals that compensatory growth ceased by day 30, whereas it continued to occur in the cranial lobe as long as 180 days post-operation. The lung DNA content in trilobectomized animals remained smaller than in the animals of the other groups demonstrating that compensatory growth was not brought about by hyperplasia. The lung RNA content in trilobectomized animals increased similarly to the lung protein content, demonstrating that the cells of the lung tissue must have had an increase in volume as no significant increase in their number occurred, as shown by the analysis of the lung DNA content. Therefore, it may be concluded that, in our experiment with adult animals, compensatory lung growth after trilobectomy in rats occurred due to an increase in the lung protein content and RNA content, suggesting a cellular volume increase (hypertrophy) and a probable increase in the intralveolar septs rather than an important cell multiplication
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86501998000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86501998000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.13 n.1 1998
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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