Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151 |
Resumo: | PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions. |
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Acta Cirúrgica Brasileira (Online) |
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Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in ratsCognitionBehaviorSimvastatinBone RegenerationRatsPURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151Acta Cirúrgica Brasileira v.29 n.3 2014reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502014000300002info:eu-repo/semantics/openAccessSousa,Dircilei Nascimento deSantana,Washington Macedo deFerreira,Vania MoraesDuarte,Wagner Rodrigueseng2015-10-26T00:00:00Zoai:scielo:S0102-86502014000300151Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2015-10-26T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
title |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
spellingShingle |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats Sousa,Dircilei Nascimento de Cognition Behavior Simvastatin Bone Regeneration Rats |
title_short |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
title_full |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
title_fullStr |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
title_full_unstemmed |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
title_sort |
Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats |
author |
Sousa,Dircilei Nascimento de |
author_facet |
Sousa,Dircilei Nascimento de Santana,Washington Macedo de Ferreira,Vania Moraes Duarte,Wagner Rodrigues |
author_role |
author |
author2 |
Santana,Washington Macedo de Ferreira,Vania Moraes Duarte,Wagner Rodrigues |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sousa,Dircilei Nascimento de Santana,Washington Macedo de Ferreira,Vania Moraes Duarte,Wagner Rodrigues |
dc.subject.por.fl_str_mv |
Cognition Behavior Simvastatin Bone Regeneration Rats |
topic |
Cognition Behavior Simvastatin Bone Regeneration Rats |
description |
PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502014000300002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.29 n.3 2014 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126442238377984 |