Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Cirúrgica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400010 |
Resumo: | PURPOSE: To study in rats the effect of S(+)ketamine on the renal histology after intraoperative hemorrhage. METHODS: Twenty male Wistar rats, anesthetized with sodium pentobarbital, were randomly divided in 2 groups: G1 - control (n=l0) and G2 - S(+)-ketamine (n=10), both submitted to arterial hemorrhage of 30% of volemia in 3 moments (10% each 10 min) 60 min after anesthesia. G2 received S(+)-ketamine, 15 mg. kg-1, i.m., 5 min after anesthesia and 55 min before the 1st hemorrhage moment (Ml). Medium arterial pressure (MAP), rectal temperature (T) and heart rate were monitored. The animals were sacrificed in M4, 30 min after the 3rd hemorrhage moment (M3) and the kidneys and blood collected from hemorrhage were utilized for histological study and hematocrit (Ht) determination. RESULTS: There were significant reduction of MAP, T, and Ht. The histological study verified G1 = G2 for tubular dilation, congestion, and necrosis. The total score addition were significant1y different and G2 > G 1. CONCLUSION: Hemorrhage and hypotension determined changes in kidney histology. The rise in catecholamine blood concentration probably was the cause of S(+)-ketamine-induced higher score of histological changes. |
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Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in ratsAnesthesia and AnalgesiaPentobarbitalKidneyIschemiaHemorrhageHypotensionHypovolemiaPURPOSE: To study in rats the effect of S(+)ketamine on the renal histology after intraoperative hemorrhage. METHODS: Twenty male Wistar rats, anesthetized with sodium pentobarbital, were randomly divided in 2 groups: G1 - control (n=l0) and G2 - S(+)-ketamine (n=10), both submitted to arterial hemorrhage of 30% of volemia in 3 moments (10% each 10 min) 60 min after anesthesia. G2 received S(+)-ketamine, 15 mg. kg-1, i.m., 5 min after anesthesia and 55 min before the 1st hemorrhage moment (Ml). Medium arterial pressure (MAP), rectal temperature (T) and heart rate were monitored. The animals were sacrificed in M4, 30 min after the 3rd hemorrhage moment (M3) and the kidneys and blood collected from hemorrhage were utilized for histological study and hematocrit (Ht) determination. RESULTS: There were significant reduction of MAP, T, and Ht. The histological study verified G1 = G2 for tubular dilation, congestion, and necrosis. The total score addition were significant1y different and G2 > G 1. CONCLUSION: Hemorrhage and hypotension determined changes in kidney histology. The rise in catecholamine blood concentration probably was the cause of S(+)-ketamine-induced higher score of histological changes.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2006-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400010Acta Cirúrgica Brasileira v.21 n.4 2006reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502006000400010info:eu-repo/semantics/openAccessRusafa Neto,EloyVianna,Pedro Thadeu GalvãoViero,Rosa MarleneMódolo,Norma Sueli PinheiroGanem,Eliana MarisaBraz,Reinaldo CerqueiraCastiglia,Yara Marcondes Machadoeng2006-09-20T00:00:00Zoai:scielo:S0102-86502006000400010Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2006-09-20T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false |
dc.title.none.fl_str_mv |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
title |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
spellingShingle |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats Rusafa Neto,Eloy Anesthesia and Analgesia Pentobarbital Kidney Ischemia Hemorrhage Hypotension Hypovolemia |
title_short |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
title_full |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
title_fullStr |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
title_full_unstemmed |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
title_sort |
Influence of S(+)-ketamine analgesia in renal intraoperative ischemia: histological study in rats |
author |
Rusafa Neto,Eloy |
author_facet |
Rusafa Neto,Eloy Vianna,Pedro Thadeu Galvão Viero,Rosa Marlene Módolo,Norma Sueli Pinheiro Ganem,Eliana Marisa Braz,Reinaldo Cerqueira Castiglia,Yara Marcondes Machado |
author_role |
author |
author2 |
Vianna,Pedro Thadeu Galvão Viero,Rosa Marlene Módolo,Norma Sueli Pinheiro Ganem,Eliana Marisa Braz,Reinaldo Cerqueira Castiglia,Yara Marcondes Machado |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rusafa Neto,Eloy Vianna,Pedro Thadeu Galvão Viero,Rosa Marlene Módolo,Norma Sueli Pinheiro Ganem,Eliana Marisa Braz,Reinaldo Cerqueira Castiglia,Yara Marcondes Machado |
dc.subject.por.fl_str_mv |
Anesthesia and Analgesia Pentobarbital Kidney Ischemia Hemorrhage Hypotension Hypovolemia |
topic |
Anesthesia and Analgesia Pentobarbital Kidney Ischemia Hemorrhage Hypotension Hypovolemia |
description |
PURPOSE: To study in rats the effect of S(+)ketamine on the renal histology after intraoperative hemorrhage. METHODS: Twenty male Wistar rats, anesthetized with sodium pentobarbital, were randomly divided in 2 groups: G1 - control (n=l0) and G2 - S(+)-ketamine (n=10), both submitted to arterial hemorrhage of 30% of volemia in 3 moments (10% each 10 min) 60 min after anesthesia. G2 received S(+)-ketamine, 15 mg. kg-1, i.m., 5 min after anesthesia and 55 min before the 1st hemorrhage moment (Ml). Medium arterial pressure (MAP), rectal temperature (T) and heart rate were monitored. The animals were sacrificed in M4, 30 min after the 3rd hemorrhage moment (M3) and the kidneys and blood collected from hemorrhage were utilized for histological study and hematocrit (Ht) determination. RESULTS: There were significant reduction of MAP, T, and Ht. The histological study verified G1 = G2 for tubular dilation, congestion, and necrosis. The total score addition were significant1y different and G2 > G 1. CONCLUSION: Hemorrhage and hypotension determined changes in kidney histology. The rise in catecholamine blood concentration probably was the cause of S(+)-ketamine-induced higher score of histological changes. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502006000400010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-86502006000400010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
Acta Cirúrgica Brasileira v.21 n.4 2006 reponame:Acta Cirúrgica Brasileira (Online) instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
instname_str |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
instacron_str |
SBDPC |
institution |
SBDPC |
reponame_str |
Acta Cirúrgica Brasileira (Online) |
collection |
Acta Cirúrgica Brasileira (Online) |
repository.name.fl_str_mv |
Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) |
repository.mail.fl_str_mv |
||sgolden@terra.com.br |
_version_ |
1752126438163611648 |